S. Halene

Impact of Memory T Cells on SARS-COV-2 Vaccine Response in Hematopoietic Stem Cell Transplant

This study evaluates SARS-CoV-2 vaccine responses in HSCT recipients, finding memory T cell defects linked to reduced T cell responses despite humoral responses.

Microfluidic immuno-serology assay revealed a limited diversity of protection against COVID-19 in patients with altered immunity

The paper develops a microfluidic immuno-serology assay to analyze immune responses in patients with altered immunity, finding reduced diversity in protein cooperation and impaired antibody responses in certain groups.

Human neutrophil development and functionality are enabled in a humanized mouse model

This study develops a humanized mouse model, MISTRGGR, that supports the generation of functional human neutrophils in circulation and tissues, which respond to inflammatory and infectious challenges.

Pre-mRNA Splicing Factor U2AF2 Recognizes Distinct Conformations of Nucleotide Variants at the Center of the pre-mRNA Splice Site Signal

This study investigates how U2AF2 recognizes different nucleotides at the center of the Py tract in pre-mRNA splice sites using structural and functional analyses.

Inflammasome activation in infected macrophages drives COVID-19 pathology

This study shows SARS-CoV-2 infection of human macrophages drives COVID-19 pathology through inflammasome activation, leading to inflammation and pyroptosis, but also enabling viral release.

Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignancies

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

MCL1 dependence across MDS subtypes and dual inhibition of MCL1 and BCL2 in MISTRG6 mice

The paper assesses MCL1 dependence in MDS subtypes and shows that combined inhibition of BCL2 and MCL1 is synergistic in vitro and reduces MDS engraftment in mice.

A Highly Efficient and Faithful MDS Patient-Derived Xenotransplantation Model for Pre-Clinical Studies

This paper develops a novel MDS patient-derived xenotransplantation model in MISTRG mice that faithfully represents all MDS subtypes and enables effective drug testing.