Author

H. Ran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:organoid / primary culture· 1 Assay:proteomics· 1

Frequent Co-Authors

B. G. Neel· 4 shared C. Foster· 2 shared I. Dolgalev· 2 shared s. zhang· 2 shared A. Koide· 1 shared B. Diskin· 1 shared C. Fedele· 1 shared D. A. Levine· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCancer Biology

B. G. Neel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

SHP2 Inhibition Abrogates Adaptive Resistance to KRASG12C-Inhibition and Remodels the Tumor Microenvironment of KRAS-Mutant Tumors

C. Fedele, S. Li, K. W. Teng, C. Foster, D. Peng, H. Ran, P. Mita, M. Geer, T. Hattori, A. Koide, Y. Wang, K. H. Tang, J. Leinwand, W. Wang, B. Diskin, , B. G. Neel

This study shows that combining SHP2 inhibitors with KRASG12C inhibitors enhances efficacy in PDAC and NSCLC by overcoming resistance and remodeling the tumor microenvironment.

bioRxiv · May 30, 2020Cancer Biology

Genetically Defined, Syngeneic Organoid Platform for Developing Combination Therapies for Ovarian Cancer

B. G. Neel, s. zhang, S. Iyer, H. Ran, W. wei, C. Foster, R. A. Weinberg

This paper develops a genetically defined, syngeneic organoid platform for ovarian cancer to evaluate combination therapies and finds genotype-specific responses to immunotherapy and chemotherapy.

bioRxiv · Apr 6, 2020Cancer Biology

Both Fallopian Tube and Ovarian Surface Epithelium Can Act as Cell-of-Origin for High Grade Serous Ovarian Carcinoma

B. G. Neel, S. Zhang, T. Zhang, I. Dolgalev, H. Ran, D. A. Levine

This paper shows that both fallopian tube and ovarian surface epithelium can originate high grade serous ovarian carcinoma, with distinct biological properties and therapeutic responses.

bioRxiv · Nov 29, 2018Cancer Biology

Off-target inhibition by active site-targeting SHP2 inhibitors

R. Tsutsumi, H. Ran, B. G. Neel

The paper shows that some SHP2 inhibitors have off-target effects on PDGFRβ and SRC, suggesting caution in interpreting their specific biological roles.

bioRxiv · Apr 5, 2018Cell Biology