Author

J. Rupp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. Zimmermann· 2 shared A. Batra· 1 shared A. Fazio· 1 shared A. Gross· 1 shared A. Hoelscher· 1 shared A. Kispert· 1 shared A. L. Greninger· 1 shared A. Munder· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

J. Zimmermann

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Delaying cefiderocol resistance development in NDM-producing Enterobacter cloacae complex by combining cefiderocol with aztreonam in vitro.

L. Goepel, T. Tran Thanh, M. T. Tran Nguyen, S. Hauswaldt, O. Nur Canbulat, J. Rupp, S. Boutin, D. Nurjadi

This study shows combining cefiderocol with aztreonam delays resistance development in NDM-producing E. cloacae complex isolates, with a 4-fold MIC reduction being a key predictor.

bioRxiv · Feb 13, 2024 · PreprintMicrobiology

Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel

L. Tueffers, A. Batra, J. Zimmermann, J. Botelho, F. Buchholz, J. Liao, N. Mendoza Mejia, A. Munder, J. Klockgether, B. Tuemmler, J. Rupp, H. Schulenburg

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

bioRxiv · Jan 15, 2024 · PreprintMicrobiology

Within-host rhinovirus evolution in upper and lower respiratory tract highlights capsid variability and mutation-independent compartmentalization

N. Makhsous, S. Goya, C. Avendano, J. Rupp, J. Kuypers, K. R. Jerome, M. Boeckh, A. Waghmare, A. L. Greninger

This study tracks HRV evolution in immunocompromised patients, finding no genetic adaptation for URT to LRT progression and highlighting capsid variability and mutation-independent compartmentalization.

bioRxiv · May 11, 2023Microbiology

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

J. Hamm, F. Hinrichsen, L. Schroder, N. Mishra, K. Shima, A. Walker, N. Sommer, K. Klischies, D. Prasse, J. Zimmermann, S. Kaiser, D. Bordoni, A. Fazio, G. Laue, V. Tremaroli, , F. Sommer

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

bioRxiv · Dec 22, 2020Immunology

WNT6-ACC2-induced accumulation of triacylglycerol rich lipid droplets is exploited by Mycobacterium tuberculosis

J. Brandenburg, S. Marwitz, S. C. Tazoll, F. Waldow, B. Kalsdorf, T. Vierbuchen, T. Scholzen, A. Gross, S. Goldenbaum, A. Hoelscher, M. Hein, L. Linnemann, M. Reimann, A. Kispert, M. Leitges, , N. Reiling

This study shows that the WNT6-ACC2 pathway promotes lipid droplet accumulation in macrophages, which Mycobacterium tuberculosis exploits for growth, and that inhibiting this pathway enhances anti-tuberculosis treatment.

bioRxiv · Jun 26, 2020 · PreprintImmunology

Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis

B. Maffei, M. Laverriere, Y. Wu, S. Triboulet, S. Perrinet, M. Duchateau, M. Matondo, R. L. Hollis, C. Gourley, J. Rupp, J. W. Keillor, A. Subtil

This study shows that TG2 activation during Chlamydia trachomatis infection enhances glucose uptake and hexosamine biosynthesis to support bacterial growth.

bioRxiv · May 10, 2019Microbiology