Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response
L. P. Deimel, X. Xue, A. Khan, L. Moynie, C. J. Buchanan, G. Sun, R. McBride, H. Schuster, C. Gauthier, R. Saliba, K. Leonavicius, L. Minall, G. Bort, R. A. Russell, E. Sezgin, , Q. J. Sattentau
This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.
bioRxiv · Jun 3, 2023 · PreprintImmunology