I. A. Sigal

This paper introduces IPOLπ, an improved version of polarized light microscopy that enhances collagen orientation discrimination and imaging speed in ocular tissues.

This paper introduces a direct fiber modeling approach to accurately represent sclera collagen microstructure and mechanics, showing it captures both fiber-level interactions and macroscale behavior better than conventional continuum models.

This paper introduces a fibrous finite element model of the optic nerve head that incorporates histology-based collagen fiber organization to study biomechanics and microstructural mechanisms.

This paper directly measures collagen fiber recruitment in the peripapillary sclera and lamina cribrosa under stretch, finding sigmoidal recruitment curves with PPS recruiting faster and at lower stretch than LC.

This study quantifies regional collagen fiber recruitment in the corneoscleral shell under intraocular pressure, showing significant variation in recruitment and fiber reserve across regions.

This paper evaluates Multicolor DiOlistic labeling (MuDi) to reveal detailed morphology of collagenous lamina cribrosa astrocytes in non-human primates and other species.

This study examines how changes in intraocular and intracranial pressures affect monkey optic nerve head morphology, finding nonlinear and non-monotonic deformations not explained by translaminar pressure difference.

The paper compares acute IOP-induced lamina cribrosa deformations in monkeys pre-mortem and post-mortem, finding similar trends but smaller pre-mortem deformations overall with local variations.

This study measures stretch-induced collagen uncrimping in sclera using polarized light microscopy and nonlinear mixed effect models, finding exponential waviness reduction with strain and sigmoidal recruitment with stretch.

This paper demonstrates that instant polarized light microscopy (IPOL) can visualize and quantify collagen morphology and architecture changes in the optic nerve head under dynamic loading.

The paper quantifies the spatial relationship between vascular and collagen networks in monkey lamina cribrosa, finding they are distinct with most beams lacking vessels and many vessels outside beams.

This paper introduces a high-accuracy and high-efficiency digital volume correlation method to analyze in-vivo optic nerve head biomechanics from OCT data, showing improved performance over conventional methods.

This study measures how changes in intraocular and intracranial pressure affect the optic nerve head in monkeys using OCT, showing significant interactions between the pressures.