Author

S. Waxman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Cell Biology· 2 Physiology· 2 Pharmacology & Toxicology· 1

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Research Focus:cell type annotation· 10 Assay:imaging· 9 Approach:experimental assay· 7 Organism:non-human primate· 5 Approach:microscopy & imaging analysis· 3 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Research Focus:clustering· 1

Frequent Co-Authors

I. A. Sigal· 6 shared C. Wang· 5 shared B. Yang· 3 shared N. A. Loewen· 3 shared P.-Y. Lee· 3 shared R. T. Loewen· 3 shared Y. Dang· 3 shared Y. Hua· 3 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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6 shared papersBioengineering

I. A. Sigal

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11 papers

Recent·Most cited

Direct measurements of collagen fiber recruitment in the posterior pole of the eye

P.-Y. Lee, G. Fryc, J. Gnalian, Y. Hua, S. Waxman, F. Zhong, B. Yang, I. A. Sigal

This paper directly measures collagen fiber recruitment in the peripapillary sclera and lamina cribrosa under stretch, finding sigmoidal recruitment curves with PPS recruiting faster and at lower stretch than LC.

bioRxiv · May 7, 2023Bioengineering

Individual Astrocyte Morphology in the Collagenous Lamina Cribrosa Revealed by Multicolor DiOlistic Labeling

S. Waxman, M. C. Quinn, C. Donahue, L. D. Falo, D. Sun, T. C. Jakobs, I. A. Sigal

This paper evaluates Multicolor DiOlistic labeling (MuDi) to reveal detailed morphology of collagenous lamina cribrosa astrocytes in non-human primates and other species.

Experimental Eye Research · May 1, 2023Peer-reviewedBioengineering

In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal

Z. Zhu, S. Waxman, B. Wang, J. Wallace, S. E. Schmitt, E. Tyler-Kabara, H. Ishikawa, J. S. Schuman, M. A. Smith, G. Wollstein, I. A. Sigal

This study examines how changes in intraocular and intracranial pressures affect monkey optic nerve head morphology, finding nonlinear and non-monotonic deformations not explained by translaminar pressure difference.

bioRxiv · Jan 29, 2023 · PreprintBioengineering

Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy

P.-Y. Lee, B. Yang, Y. Hua, S. Waxman, Z. Zhu, F. Ji, I. A. Sigal

This paper demonstrates that instant polarized light microscopy (IPOL) can visualize and quantify collagen morphology and architecture changes in the optic nerve head under dynamic loading.

bioRxiv · Oct 3, 2021Bioengineering

Lamina cribrosa vessel and collagen beam networks are distinct

S. Waxman, B. L. Brazile, B. Yang, A. L. Gogola, Y. Hua, P. Lam, P.-Y. Lee, A. P. Voorhees, J. F. Rizzo, T. C. Jakobs, I. A. Sigal

The paper quantifies the spatial relationship between vascular and collagen networks in monkey lamina cribrosa, finding they are distinct with most beams lacking vessels and many vessels outside beams.

bioRxiv · Oct 3, 2021Bioengineering

Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo

Z. Zhu, S. Waxman, B. Wang, J. Wallace, S. E. Schmitt, E. Tyler-Kabara, H. Ishikawa, J. S. Schuman, M. A. Smith, G. Wollstein, I. A. Sigal

This study measures how changes in intraocular and intracranial pressure affect the optic nerve head in monkeys using OCT, showing significant interactions between the pressures.

bioRxiv · Dec 14, 2020Bioengineering

Ripasudil in a model of pigmentary glaucoma

C. Wang, Y. Dang, S. Waxman, Y. Hong, P. Shah, R. T. Loewen, X. Xia, N. Loewen

This study evaluates Ripasudil's effects on pigmentary glaucoma in a porcine model, showing reduced trabecular meshwork stress fibers, restored phagocytosis, and normalized intraocular pressure.

bioRxiv · May 4, 2020Pharmacology & Toxicology

3D-Reconstruction of the Human Conventional Outflow System by Ribbon Scanning Confocal Microscopy

R. Loewen, S. Waxman, C. Wang, S. Atta, S. Chen, S. C. Watkins, A. M. Watson, N. A. Loewen

This study uses ribbon-scanning confocal microscopy to compare the outflow tract anatomy of human and porcine eyes, finding humans have fewer and larger collector channels.

bioRxiv · Jan 17, 2020Physiology

Dose-dependent effects of netarsudil, a Rho-kinase inhibitor, on the distal outflow tract

S. Chen, S. Waxman, C. Wang, S. Atta, R. Loewen, N. A. Loewen

This study examines how different doses of netarsudil affect intraocular pressure and vessel diameter in porcine anterior segments with and without trabecular meshwork removal.

bioRxiv · Jan 17, 2020Physiology

Intraocular pressure elevation precedes a phagocytosis decline in a model of pigmentary glaucoma

Y. Dang, S. Waxman, C. Wang, R. T. Loewen, N. A. Loewen

This study shows that intraocular pressure elevation occurs before phagocytosis decline in a porcine model of pigmentary glaucoma, indicating separate mechanisms for these phenomena.

bioRxiv · Aug 13, 2017Cell Biology

A porcine ex vivo model of pigmentary glaucoma

Y. Dang, S. Waxman, C. Wang, R. T. Loewen, M. Sun, N. Loewen

This study develops a porcine ex vivo model of pigmentary glaucoma, showing intraocular hypertension, pigment accumulation, and impaired phagocytosis in trabecular meshwork cells, with RhoA identified as a key regulator.

bioRxiv · Aug 11, 2017Cell Biology