F. Ji

CCT3 drives Sorafenib resistance by inhibiting TFRC-mediated iron uptake in HCC

This study identifies CCT3 as a driver of Sorafenib resistance in HCC by inhibiting TFRC-mediated iron uptake, leading to ferroptosis resistance.

Fibrous Finite Element Modeling of the Optic Nerve Head Region

This paper introduces a fibrous finite element model of the optic nerve head that incorporates histology-based collagen fiber organization to study biomechanics and microstructural mechanisms.

A direct fiber approach to model sclera collagen architecture and biomechanics

This paper introduces a direct fiber modeling approach to accurately represent sclera collagen microstructure and mechanics, showing it captures both fiber-level interactions and macroscale behavior better than conventional continuum models.

Regulation of interstitial fluid flow along adventitia of vasculature by heartbeat and respiration

The paper identifies a circulatory pathway for interstitial fluid flow along vasculature adventitia in rats, regulated by heartbeat and respiration.

Comprehensive analysis identifies histone 2A ubiquitination as a marker for aging and pan-cancer prognosis

The paper analyzes aging and cancer by profiling ubiquitinome and RNA-seq data in mice, identifying H2A ubiquitination as a marker linked to prognosis and tumor microenvironment.

Integrative interactome and ubiquitinome analyses reveal multiple regulatory pathways targeted by ICP0 in HSV-1 infected neuronal cells

This study identifies and validates multiple novel targets of HSV-1 ICP0 in neuronal cells using proteomic approaches and functional experiments, revealing potential restrictive activities of SNX9 and OTUD4.

METTL3 promotes homologous recombination repair and modulates chemotherapeutic response by regulating the EGF/Rad51 axis

This study identifies METTL3's role in promoting homologous recombination repair and modulating chemotherapeutic response in breast cancer cells by regulating the EGF/RAD51 axis through m6A modification.

Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy

This paper demonstrates that instant polarized light microscopy (IPOL) can visualize and quantify collagen morphology and architecture changes in the optic nerve head under dynamic loading.

Single-cell transcriptome analysis reveals mesenchymal stem cells in cavernous hemangioma

This study identifies mesenchymal stem cells in cavernous hemangioma using scRNA-seq and proposes their origin from epiblast stem cells, along with new cell types and molecular mechanisms involved in tumor formation and immune responses.

An intranasal ASO therapeutic targeting SARS-CoV-2

This paper develops an intranasal ASO therapy targeting SARS-CoV-2 RNA that effectively prevents viral replication in multiple models and variants.

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche

The paper shows that stress-induced extracellular vesicles transfer tiRNAs to hematopoietic progenitors, enhancing myeloid recovery and survival.

Integrative Proteomic Analysis of Posttranslational Modification in The Inflammatory Response

This study integrates proteomic data from human and mouse macrophages to analyze posttranslational modifications in the inflammatory response, identifying PTM crosstalk and novel inflammatory proteins.

Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals a Broad Potential Host Range of SARS-CoV-2

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.