Differential roles of beta-cell IP3R and RyR ER Ca2+ channels in ER stress-induced alterations of beta-cell Ca2+ homeostasis
I. X. Zhang, A. Hermann, J. Leon…·L. Satin
This study investigates how ER stress affects IP3R and RyR Ca2+ channels in beta cells, showing RyR1 dysfunction contributes to Ca2+ dysregulation and apoptosis.