J. B. Hein

The paper reports cryo-EM structures of PP2A:B55 bound to phosphorylated ARPP19 and FAM122A, revealing distinct binding mechanisms and providing insights for therapeutic development.

The paper develops an in vitro assay to determine phosphatase specificity and applies it to study mitotic exit, revealing substrate preferences and biological relevance.

The paper compares MRBLE-pep and ITC measurements of B56 binding affinities, showing MRBLE-pep accurately quantifies relative affinity with less material.

The paper introduces MRBLEs 2.0, a method for high-throughput synthesis of functionalized microspheres with spectral and magnetic encoding, demonstrating efficient conjugation of biomolecules and magnetic nanoparticle incorporation.