Author

A. Singapuri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:non-human primate· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

K. K. A. Van Rompay· 3 shared L. L. Coffey· 3 shared A. Panganiban· 2 shared B. Schouest· 2 shared J. B. Stuart· 2 shared J. Usachenko· 2 shared J. Watanabe· 2 shared N. Maness· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersPathology

K. K. A. Van Rompay

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4 papers

Recent·Most cited

Zika virus persistence in the male macaque reproductive tract

E. E. Ball, P. A. Pesavento, K. K. A. Van Rompay, M. K. Keel, A. Singapuri, J. P. Gomez-Vazquez, D. M. Dudley, D. OConnor, M. E. Breitbach, N. Maness, B. Schouest, A. Panganiban, L. L. Coffey

This study investigates ZIKV persistence in male macaque reproductive tissues, finding prolonged viral presence in germ and epithelial cells and potential impacts on fertility.

bioRxiv · Mar 3, 2022Pathology

Two sides of a coin: a Zika virus mutation selected in pregnant rhesus macaques promotes fetal infection in mice but at a cost of reduced fitness in nonpregnant macaques and diminished transmissibility by vectors

D. Lemos, J. B. Stuart, W. Louie, A. Singapuri, A. L. Ramirez, J. Watanabe, J. Usachenko, R. Keesler, C. Sanchez-San Martin, T. Li, C. Martyn, G. Oliveira, S. Saraf, N. D. Grubaugh, K. Andersen, , L. L. Coffey

This paper identifies a ZIKV mutation, M1404I, that enhances fetal infection in mice but reduces viral fitness and transmissibility in nonpregnant macaques and mosquitoes.

bioRxiv · Aug 11, 2020Microbiology

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

K. K. A. Van Rompay, L. L. Coffey, T. Kapoor, A. Gazumyan, R. I. Keesler, A. Jurado, A. Peace, M. Agudelo, J. Watanabe, J. Usachenko, A. Singapuri, R. Immareddy, A. Ardeshir, J. B. Stuart, S. Bournazos, , D. F. Robbiani

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

bioRxiv · Jan 31, 2020Immunology

Maternal antibodies provide partial protection from postnatal Zika viremia in nonhuman primates

N. Maness, B. Schouest, A. Singapuri, M. Dennis, M. Gilbert, R. Bohm, F. Schiro, P. Aye, K. Baker, K. Van Rompay, A. Lackner, M. Bonaldo, R. Blair, S. Permar, L. Coffey, , D. Magnani

This study shows that maternal antibodies provide partial protection against postnatal Zika virus infection in infant nonhuman primates, reducing viremia but not completely preventing viral dissemination.

bioRxiv · Apr 18, 2019Microbiology