L. L. Coffey

Microbial exposure across life reduces susceptibility of Aedes aegypti to Zika virus by enhancing blood digestion and limiting midgut cell infection

Human influenza A virus H1N1 1 in marine mammals in California, 2019

The paper reports the detection of human H1N1 influenza A virus in northern elephant seals in California in 2019, indicating continued zoonotic transmission from humans to marine mammals.

Zika virus persistence in the male macaque reproductive tract

This study investigates ZIKV persistence in male macaque reproductive tissues, finding prolonged viral presence in germ and epithelial cells and potential impacts on fertility.

N-dihydrogalactochitosan reduces mortality in a lethal mouse model of SARS-CoV-2

N-dihydrogalactochitosan reduces mortality and morbidity in a lethal SARS-CoV-2 mouse model by lowering viral load and improving survival.

Microbial composition in larval water enhances Aedes aegypti development but reduces transmissibility of Zika virus

This study shows that rearing Aedes aegypti in cemetery water reduces ZIKV transmissibility compared to tap water, despite higher bacterial diversity in the environmental water.

Respiratory tract explant infection dynamics of influenza A virus in California sea lions, northern elephant seals, and rhesus macaques

This study uses respiratory tract explants from marine mammals and rhesus macaques to compare influenza A virus infection kinetics across species.

Two sides of a coin: a Zika virus mutation selected in pregnant rhesus macaques promotes fetal infection in mice but at a cost of reduced fitness in nonpregnant macaques and diminished transmissibility by vectors

This paper identifies a ZIKV mutation, M1404I, that enhances fetal infection in mice but reduces viral fitness and transmissibility in nonpregnant macaques and mosquitoes.

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques

This study shows that two Fc-modified monoclonal antibodies limit fetal neurologic damage and vertical transmission of ZIKV in pregnant macaques.

An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar

The paper evaluates PrimalSeq for measuring intrahost virus diversity, showing how factors like sequencing coverage and primer mismatches affect accuracy.