Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes
A. Sawant, F. Shi, E. C. Lopes, Z. Hu, S. Abdelfattah, J. Baul, J. Powers, C. Hinrichs, J. Rabinowitz, C. Chan, E. Lattime, S. Ganesan, E. White
This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.
bioRxiv · Jun 10, 2024 · PreprintCancer Biology