J. Powers

Immune Checkpoint Blockade Delays Cancer and Extends Survival in Murine DNA Polymerase Mutator Syndromes

This paper shows that immune checkpoint blockade (ICB) can delay cancer onset and improve survival in mice with mutator syndromes, but only if administered prophylactically before tumors develop.

Next-generation mapping of the salicylic acid signaling hub and transcriptional cascade

This study maps the NPR1 signaling hub and transcriptional cascade in plants using TurboID and greenCUT&RUN, revealing chromatin remodeling and histone demethylation in SA-induced resistance.

Fc mediated pan-sarbecovirus protection after alphavirus vector vaccination

This study shows that non-neutralizing antibodies targeting FcR4 and spike S2 provide cross-protection against sarbecoviruses after alphavirus vector vaccination.

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

This study shows CD4 T cell help enhances CD8 T cell function and prevents exhaustion during M. tuberculosis infection, suggesting vaccines targeting both cell types may be more effective.

Invasion by Fusobacterium nucleatum Causes Upregulation of dll4 and klf4 Expression in Caco-2 Cells

The paper investigates how invasive Fusobacterium nucleatum strains upregulate host genes dll4 and klf4 in Caco-2 cells compared to a non-invasive E. coli control.

Eating breakfast and avoiding the evening snack sustains lipid oxidation

This study shows that eating breakfast instead of an evening snack increases lipid oxidation in older adults, highlighting the impact of meal timing on metabolism.

Short hairpin RNAs artifactually impair cell growth and suppress clustered microRNA expression.

This study shows that shRNAs impair cell growth and suppress microRNA expression in a sequence-independent manner, highlighting potential artifacts in cancer research.