J. Champer

Resource-explicit interactions in spatial population models

This paper introduces a resource-explicit modeling method for spatial population models that improves computational efficiency while maintaining accuracy.

First-male sperm precedence in polyandrous Spodoptera frugiperda allows sterile males induce population suppression

This study identifies first-male sperm precedence in fall armyworms and shows sterile males can suppress pest populations through sperm competition mechanisms.

Overriding Mendelian inheritance in Arabidopsis with a CRISPR toxin-antidote gene drive that impairs pollen germination

This study develops a CRISPR-based gene drive in Arabidopsis to override Mendelian inheritance by targeting pollen germination, achieving high transmission rates with minimal resistance.

Simulations reveal high efficiency and confinement of a population suppression CRISPR toxin-antidote gene drive

This study uses simulations to show that TADE suppression gene drives are more confined in continuous space and can suppress populations effectively under certain conditions.

Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models

The paper models how adversarial interspecies relationships can enhance gene drive suppression in spatially structured populations, showing both benefits and risks for population elimination.

Modelling homing suppression gene drive in haplodiploid organisms

This paper models homing suppression gene drives in haplodiploid organisms and finds they can be effective despite challenges like resistance and reduced drive power compared to diploids.

Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations

This study evaluates fitness costs of CRISPR/Cas9 in Drosophila by tracking allele frequencies of transgenic constructs, finding moderate off-target costs but no direct Cas9 costs, with Cas9HF1 minimizing off-target effects.

Modeling CRISPR gene drives for suppression of invasive rodents

The paper models CRISPR gene drives for rodent population suppression and finds they can eliminate island populations if resistance is minimized.

Suppression gene drive in continuous space can result in unstable persistence of both drive and wild-type alleles

This study shows that suppression gene drives in spatial models can lead to unstable persistence of both drive and wild-type alleles due to chasing dynamics.

Maximum likelihood estimation of fitness components in experimental evolution

The paper develops a maximum likelihood framework to estimate fitness components in experimental evolution using Drosophila melanogaster data, finding reduced mating preference and viability for a yellow allele.