V. Patel

Novel sex-biased outcomes in neuroblastoma are associated with distinct gene expression and chromosomal loss patterns.

The paper identifies sex-biased outcomes in neuroblastoma, showing female patients with MYCN non-amplified high-risk disease have worse survival than males, linked to H19/DLK1 expression and chromosome 11q retention.

Ultra-high dose oral ω3 docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) block tumorigenesis in a MYCN-driven neuroblastoma model

This paper shows that ultra-high dose omega-3 fatty acids block tumor formation in a neuroblastoma model, while omega-6 fatty acids promote it.

Fecal microbial transfer and complex carbohydrates mediate protection against COPD

This study shows that fecal microbial transfer and complex carbohydrates can reduce COPD symptoms in mice and humans, linking gut microbiota to disease progression.

Differential evolution of cooperative traits in aggregative multicellular bacterium Myxococcus xanthus driven by varied population bottleneck sizes

This study shows that varying population bottleneck sizes in Myxococcus xanthus influence the evolution of cooperative traits, with stringent bottlenecks favoring fruiting body formation and growth while relaxed bottlenecks enhance overall fitness.

Low intensity mechanical signals promote proliferation in a cell-specific manner: Tailoring a non-drug strategy to enhance biomanufacturing yields.

The paper tests low-intensity vibration to enhance cell proliferation in biomanufacturing, showing it can be tailored to different cell types to improve yields.

Maximization of Energy Recovery from Starch Processing Wastewater by Thermophilic Dark Fermentation Coupled with Microbial fuel Cell Technology

This study maximizes energy recovery from starch wastewater using thermophilic dark fermentation combined with microbial fuel cells, achieving high hydrogen production and COD reduction.

A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites

This study identifies a transcriptional network involving var2csa that coordinates var gene switching in malaria parasites, explaining how they maintain chronic infections by limiting antigen exposure.

Using axenic and gnotobiotic insects to examine the role of different microbes on the development and reproduction of the kissing bug Rhodnius prolixus (Hemiptera: Reduviidae)

This study shows that Rhodococcus rhodnii provides greater fitness benefits to Rhodnius prolixus than other bacteria, despite similar B vitamin synthesis capabilities.

Adaptation and Compensation in a Bacterial Gene Regulatory Network Evolving Under Antibiotic Selection

This study shows that E. coli evolves trimethoprim tolerance through PhoPQ de-repression and later resistance via DHFR mutations or cost compensation via RpoS inactivation, depending on antibiotic selection strength.

Epigenetic reprogramming ameliorates type 1 diabetes by decreasing the generation of Th1 and Th17 subsets and restoring self-tolerance in CD4+ T cells

This study shows that the histone modifier TSA reduces Th1 and Th17 cell generation and restores self-tolerance in CD4+ T cells, ameliorating type 1 diabetes in NOD mice.

The evolutionary dynamics of genetic incompatibilities introduced by duplicated genes in Arabidopsis thaliana

The paper identifies genetic incompatibilities from duplicated genes in Arabidopsis thaliana using GWAS and natural population data, showing how these incompatibilities coexist and are mitigated by additional gene copies.

Integrated RNA and metabolite profiling of urine liquid biopsies for prostate cancer biomarker discovery

The paper identifies urine-enriched RNAs and metabolites in prostate cancer patients and normal individuals, revealing altered glutamate metabolism and TCA cycle in cancer cells.

The CNS in the face of ART contains T cell origin HIV which can lead to drug resistance

The paper investigates the origin of HIV in the CNS of ART-suppressed individuals and finds T cell-derived HIV that can lead to drug resistance.

A real-time PCR for the differentiation of typhoidal and non-typhoidal Salmonella

This paper develops a real-time PCR assay to rapidly and accurately differentiate typhoidal and non-typhoidal Salmonella with 100% sensitivity and specificity.

Cargo Transport Shapes the Spatial Organization of a Microbial Community

The paper shows that gliding bacteria, specifically Capnocytophaga gingivalis, transport non-motile bacteria as cargo, shaping the spatial organization of polymicrobial communities.

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in mice

This study shows that mice lacking PPP1R15A gain less weight and have improved insulin sensitivity on a high-fat diet but not on standard diet.