Author

G. Ebert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. Frank· 2 shared J. M. Murphy· 2 shared K. E. Lawlor· 2 shared M. Doerflinger· 2 shared R. Feltham· 2 shared A. E. Au· 1 shared A. Herrmann· 1 shared A. I. Webb· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

D. Frank

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural elucidation and antiviral activity of cathepsin L inhibitors with carbonyl and epoxide warheads

S. Falke, J. Lieske, A. Herrmann, J. Loboda, S. Gunther, P. Y. A. Reinke, W. Ewert, K. Karnicar, A. Usenik, N. Lindic, A. Sekirnik, H. Tsuge, V. Turk, H. N. Chapman, W. Hinrichs, , A. Meents

The paper presents crystal structures of cathepsin L inhibitors and evaluates their antiviral activity against SARS-CoV-2.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

S. E. Garnish, K. R. Martin, M. Kauppi, V. Jackson, R. Ambrose, V. V. Eng, S. Chiou, Y. Meng, D. Frank, E. C. Tovey Crutchfield, K. M. Patel, A. Jacobsen, G. Atkin-Smith, L. Di Rago, M. Doerflinger, , J. Hildebrand

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

bioRxiv · Sep 8, 2022 · PreprintImmunology

The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

S. Vijayaraj, R. Feltham, M. Rashidi, D. Frank, Z. Liu, D. Simpson, G. Ebert, A. Vince, M. J. Herold, A. J. Kueh, J. Pearson, L. Dagley, J. M. Murphy, A. I. Webb, K. E. Lawlor, J. E. Vince

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

bioRxiv · Mar 15, 2021 · PreprintImmunology

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry