Author

J. F. Diffley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 7 Approach:experimental assay· 7 Organism:human· 3 Assay:proteomics· 2

Frequent Co-Authors

B. Canal· 7 shared F. Weissmann· 7 shared M. Howell· 7 shared M. Wu· 7 shared R. Beale· 7 shared R. Ulferts· 7 shared L. S. Drury· 6 shared J. Milligan· 5 shared

Activity by Year

2021-2021 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersBiochemistry

B. Canal

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp12/7/8 RNA-dependent RNA Polymerase

R. Beale, A. P. Bertolin, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, J. Milligan, V. Posse, R. Ulferts, F. Weissmann, M. Wu, J. Zeng

This study screens a chemical library to identify SARS-CoV-2 RdRp inhibitors, finding three novel compounds and confirming suramin-like compounds as inhibitors.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of nsp5 Main Protease

C. Basier, R. Beale, G. Bineva-Todd, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, R. Fujisawa, M. Howell, D. Joshi, K. Labib, C. T. Lim, J. Milligan, H. Nagaraj, N. O'Reilly, , T. U. Zeisner

This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease

C. Basier, S. Basu, R. Beale, A. P. Bertolin, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, J. Milligan, E. Roberts, , J. Zeng

This study identifies patulin and aurintricarboxylic acid as inhibitors of SARS-CoV-2 nsp14 exoribonuclease, showing antiviral activity in cell culture.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp3 Papain-like Protease

L. A. Armstrong, R. Beale, G. Bineva-Todd, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, Y. Kulathu, K. Labib, C. T. Lim, J. Milligan, N. O'Reilly, E. Ozono, K. W. Tan, R. Ulferts, , J. Zeng

This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp15 Endoribonuclease

R. Beale, A. P. Bertolin, B. Canal, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, A. W. McClure, R. Ulferts, F. Weissmann, M. Wu, J. Zeng

This study screens for small molecule inhibitors of SARS-CoV-2 nsp15 endoribonuclease and identifies NSC95397 as an in vitro inhibitor, though its antiviral efficacy remains to be determined.

bioRxiv · Apr 7, 2021Biochemistry

Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp13 Helicase

R. Beale, A. P. Bertolin, A. Borg, B. Canal, J. F. Diffley, L. S. Drury, R. Harvey, M. Howell, S. Hussain, S. Kjaer, J. McCauley, L. McCoy, J. Milligan, V. Posse, C. Roustan, , J. Zeng

This study identifies small molecule inhibitors of SARS-CoV-2 nsp13 helicase by screening a chemical library and validates their antiviral efficacy in cell culture.

bioRxiv · Apr 7, 2021Biochemistry

Identification of SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase

C. Basier, S. Basu, R. Beale, B. Canal, V. H. Cowling, J. F. Curran, T. D. Deegan, J. F. Diffley, L. S. Drury, R. Fujisawa, M. Howell, K. Labib, C. T. Lim, T. Mak, A. W. McClure, , T. U. Zeisner

This study identifies four small molecule inhibitors of SARS-CoV-2 nsp14 RNA cap methyltransferase, with three showing synergy with remdesivir in antiviral assays.

bioRxiv · Apr 7, 2021Bioengineering