Author

J. Ferruzzi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:imaging· 1

Frequent Co-Authors

M. H. Zaman· 3 shared D. Roblyer· 2 shared J. J. Fredberg· 2 shared J. P. Butler· 2 shared A. F. Pegoraro· 1 shared B. G. Leshnower· 1 shared C. Y. Park· 1 shared C.-P. Spatarelu· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

M. H. Zaman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Effect of Aging, Sex, and Gene (Fbln5) on Arterial Stiffness of Mice: 20 Weeks Adult Fbln5-knockout Mice Have Older Arteries than 100 Weeks Wild-Type Mice

H. Dong, J. Ferruzzi, M. Liu, L. P. Brewster, B. G. Leshnower, R. L. Gleason

This study shows that Fbln5 gene knockout in mice significantly increases arterial stiffness, equivalent to aging 51 years in humans, and introduces a new UFD model for more accurate biomechanical analysis.

bioRxiv · May 30, 2023 · PreprintBioengineering

An exploratory study on the role of the stiffness of breast cancer cells in their detachment from spheroids and migration in 3D collagen matrices

G. Higgins, J. E. Kim, J. Ferruzzi, T. Abdalrahman, T. Franz, M. H. Zaman

This study investigates how breast cancer cell stiffness changes during detachment from spheroids and migration in 3D collagen matrices, finding that decreased stiffness facilitates detachment and migration.

bioRxiv · Jan 21, 2021 · PreprintCancer Biology

Epithelial layer unjamming shifts energy metabolism toward glycolysis

S. J. DeCamp, V. M. K. Tsuda, J. Ferruzzi, S. A. Koehler, D. Roblyer, J. T. Giblin, M. H. Zaman, S. T. Weiss, M. DeMarzio, C. Y. Park, N. C. Ogassavara, J. A. Mitchel, J. P. Butler, J. J. Fredberg

The paper shows that during epithelial layer unjamming, cells shift their metabolism toward glycolysis, even in regions without visible morphological changes.

bioRxiv · Jun 30, 2020Biophysics

Tumor invasion as non-equilibrium phase separation

W. Kang, J. Ferruzzi, C.-P. Spatarelu, Y. L. Han, Y. Sharma, S. Koehler, J. P. Butler, D. Roblyer, M. H. Zaman, M. Guo, Z. Chen, A. F. Pegoraro, J. J. Fredberg

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

bioRxiv · Apr 28, 2020 · PreprintBiophysics