A. Choi

Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

This study shows that vimentin cytoskeleton assembly is sensitive to net charge states and Coulomb repulsion, with hypotonic stress causing rapid disassembly due to reduced charge screening.

SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

This study reports a serosurvey of cats in New York City during the early pandemic, finding 16% seropositive for SARS-CoV-2 with higher prevalence in fall 2020 and evidence of human-cat transmission.

Protocol for primary human lung organoid-derived air-liquid interface in vitro model to study response to SARS-CoV-2

This paper presents a protocol for creating human lung organoid-derived air-liquid interface cultures to study SARS-CoV-2 infection and includes quality control and monitoring methods.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

Human Saliva Modifies Growth, Biofilm Architecture and Competitive Behaviors of Oral Streptococci

This study shows that human saliva affects growth, biofilm structure, and competitive interactions between oral streptococci species.

Spatiotemporally organized immunomodulatory response to SARS-CoV-2 virus in primary human broncho-alveolar epithelia

This study examines the spatiotemporal immune response to SARS-CoV-2 in human broncho-alveolar epithelia, finding variant-specific kinetics and spatially organized gene expression patterns.

HBV rewires liver cancer signaling by altering PP2A complexes

This study identifies how HBV alters PP2A complexes to drive liver cancer signaling, revealing potential therapeutic targets.

Bioinformatic analysis of the spike protein cleavage sites of coronaviruses in the mammalian order Eulipotyphla

The paper analyzes coronavirus spike protein cleavage sites in Eulipotyphla mammals, finding potential spillover risks in certain shrew coronaviruses.

Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes

This study identifies natural selection differences in key protein domains between non-pathogenic FECV and pathogenic FIPV FCoVs, highlighting sites under positive selection associated with FIP development.

Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)

The paper analyzes the molecular determinants of furin cleavage of MHV spike protein S1/S2 site, identifying structural requirements and sequence variations affecting cleavage efficiency.

Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

The paper develops and evaluates an mRNA vaccine, mRNA-1283, encoding SARS-CoV-2 spike N-terminal and receptor-binding domains, showing improved immunogenicity and protection against multiple variants in mice.

Distinct sensitivities to SARS-CoV-2 variants in vaccinated humans and mice

This study compares neutralizing antibody responses to SARS-CoV-2 variants in vaccinated humans and mice, finding that mice do not accurately reflect the breadth and potency seen in humans.

In vitro and computational analysis of the putative furin cleavage site (RRARS) in the divergent spike protein of the rodent coronavirus AcCoV-JC34 (sub-genus luchacovirus)

The paper analyzes the spike protein of AcCoV-JC34, identifying a putative furin cleavage site that is not cleaved by furin, suggesting a potential progenitor sequence for viral emergence.

Non-Invasive Skin Sampling Detects Systemically Administered Drugs in Humans

This study shows that skin swabs combined with mass spectrometry can detect systemically administered drugs and their metabolites in humans.

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

mRNA-1273 boosted nonhuman primates show increased neutralizing antibody responses and protection against SARS-CoV-2 beta variant infection.

Displacement statistics of unhindered single molecules show no enhanced diffusion in enzymatic reactions

The paper measures diffusion coefficients of four enzymes under catalytic conditions and finds no enhanced diffusion.

Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants

This study evaluates the neutralizing activity of mRNA-1273 vaccine-induced sera against SARS-CoV-2 variants, finding reduced but still effective neutralization against several variants compared to the wild-type virus.

Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

This study evaluates mRNA-1273 vaccine efficacy against SARS-CoV-2 B.1.351 in nonhuman primates, finding that two doses significantly reduce viral replication in the airways.

Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

This study shows that mRNA-1273 vaccine-induced antibody responses correlate with protection against SARS-CoV-2 infection in nonhuman primates.

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

This study evaluates the neutralizing antibody response of mRNA-1273 vaccine against SARS-CoV-2 variants B.1.1.7 and B.1.351 using pseudovirus neutralization assays.

Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Modified Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine

This paper demonstrates that a novel TLR7/8 agonist adjuvant enables single-shot protection against SARS-CoV-2 and influenza in mice using recombinant spike protein and inactivated vaccines.

The use of a chimeric rhodopsin vector for the detection of new proteorhodopsins based on color

This paper describes a functional assay using a chimeric rhodopsin vector to detect proteorhodopsins without sequencing, enabling rapid visual results in marine microbiology courses.