Author

A. Goga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

J. V. Lee· 3 shared J. Winkler· 3 shared H. S. Rugo· 2 shared O. Momcilovic· 2 shared R. Camarda· 2 shared S. Kilinc· 2 shared A. Abbasi· 1 shared A. Detweiler· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

J. V. Lee

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force

R. Sutanto, L. Neahring, A. S. Marques, S. Kilinc, A. Goga, S. Dumont

This study shows cyclin D1 overexpression increases spindle abnormalities but protects against pole fracture under compressive force, potentially aiding cancer cell survival in solid tumors.

bioRxiv · May 30, 2023 · PreprintCell Biology

Respiratory Complex I Regulates Dendritic Cell Maturation in Explant Model of Human Tumor Immune Microenvironment

R. Turpin, R. Liu, P. Munne, A. Peura, J. H. Rannikko, G. Philips, B. Boeckx, N. Salmelin, E. Hurskainen, I. Suleymanova, E. M. Vuorinen, L. Lehtinen, M. Mutka, P. E. Kovanen, L. Niinikoski, , J. Klefstrom

The paper uses a patient-derived explant model to show metformin enhances dendritic cell maturation by inhibiting complex I, improving anti-tumor immunity when combined with venetoclax.

bioRxiv · May 10, 2023Cancer Biology

Dissecting the contributions of tumor heterogeneity on metastasis at single-cell resolution

J. Winkler, W. Tan, C. M. M. Diadhiou, C. S. McGinnis, A. Abbasi, S. Hasnain, S. Durney, E. Atamaniuc, D. Superville, L. Awni, J. V. Lee, J. H. Hinrichs, M. Y. Hein, M. Borja, A. Detweiler, , Z. Werb

This study analyzes single-cell transcriptomes of primary tumors and metastases from breast cancer models, identifying transcriptional differences and gene signatures linked to metastatic potential and patient outcomes.

bioRxiv · Aug 4, 2022 · PreprintCancer Biology

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

A. Navickas, H. Asgharian, J. Winkler, L. Fish, K. Garcia, D. Markett, M. Dodel, B. Culbertson, S. Miglani, T. Joshi, P. Nguyen, S. Zhang, N. Stevers, H.-W. Hwang, F. Mardakheh, , H. Goodarzi

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

bioRxiv · Oct 4, 2021Cancer Biology

Combinatorial immunotherapies overcome MYC-driven immune evasion

J. V. Lee, F. Houseley, C. Yau, D. Van de Mark, R. Nakagawa, G. Hemmati, G. A. Hernandez, J. Winkler, Y. Zhang, S. Samson, C. Baas, L. J. Esserman, L. J. Van't Veer, H. S. Rugo, M. Matloubian, A. Goga

This study shows that MYC-driven immune evasion in TNBC can be reversed by combining immunotherapies, leading to tumor regression in mice.

bioRxiv · May 7, 2021Cancer Biology

In vivo optical metabolic imaging of long-chain fatty acid uptake in orthotopic models of triple negative breast cancer

M. C. Madonna, J. E. Duer, J. V. Lee, J. Williams, B. Avsaroglu, C. Zhu, R. Deutsch, R. Wang, B. Crouch, M. Hirschey, A. Goga, N. Ramanujam

This study develops an in vivo optical imaging method to quantify long-chain fatty acid uptake in breast cancer models, showing reduced uptake with MYC downregulation and increased uptake with tumor aggressiveness.

bioRxiv · Nov 2, 2020Bioengineering

Oncogene Regulated Release of Extracellular Vesicles

S. Kilinc, R. Paisner, R. Camarda, O. Momcilovic, R. A. Kohnz, N. D. L'Etoile, R. M. Perera, D. M. Nomura, A. Goga

This study shows specific oncogenes reduce cancer cell biomass by promoting extracellular vesicle release, with distinct effects on EV protein and miRNA composition.

bioRxiv · Apr 4, 2020Cell Biology

Kinome rewiring reveals AURKA is a molecular barrier to the efficacy of PI3K/mTOR-pathway inhibitors in breast cancer

H. J. Donnella, J. T. Webber, R. S. Levin, R. Camarda, O. Momcilovic, N. Bayani, K. N. Shah, J. Korkola, K. M. Shokat, A. Goga, J. Gordan, S. Bandyopadhyay

The paper identifies AURKA as a barrier to PI3K/mTOR inhibitor efficacy in breast cancer by mapping kinome dynamics and showing that AURKA inhibition synergizes with these drugs to induce apoptosis and tumor regression.

bioRxiv · Jun 30, 2017Cancer Biology