Author

J. Lees

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Alshayeb· 1 shared A. Amon· 1 shared A. Antebi· 1 shared A. Bhutkar· 1 shared A. F. Khan· 1 shared A. Gueler· 1 shared A. Heinen· 1 shared A. Holroyd· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Alshayeb

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling

J. Hay, A. Tarafdar, A. Holroyd, H. A. Moka, K. M. Dunn, A. Alshayeb, B. H. Lloyd, J. Cassels, N. Malik, A. F. Khan, I. Sou, J. Lees, H. N. Almuhanna, N. Kalakonda, J. R. Slupsky, A. M. Michie

This study shows PKCβ promotes CLL by enhancing BCR signaling and identifies SP1 as a regulator of PKCβ expression in leukemogenesis.

bioRxiv · Sep 4, 2022 · PreprintCancer Biology

An EMT-primary cilium-GLIS2 signaling axis regulates mammogenesis and claudin-low breast tumorigenesis

M. M. Wilson, C. Callens, M. Le Gallo, S. Mironov, Q. Ding, A. Salamagnon, T. Chavarria, A. Peasah, A. Bhutkar, S. Martin, F. Godey, P. Tas, A. Jetten, J. E. Visvader, R. Weinberg, , V. Guen

This study identifies an EMT-primary cilium-GLIS2 signaling axis that regulates mammary stem cell properties and claudin-low breast tumorigenesis.

bioRxiv · Dec 29, 2020Cell Biology

Cell size is a determinant of stem cell potential during aging

J. Lengefeld, C.-W. Cheng, P. Maretich, M. R. McReynolds, M. Blair, H. Hagen, E. J. Sullivan, K. Majors, C. Roberts, J. H. Kang, J. Steiner, T. P. Miettinen, S. Manalis, A. Antebi, S. J. Morrison, , A. Amon

The paper shows that stem cell enlargement during aging reduces their function, and preventing this enlargement improves function.

bioRxiv · Oct 27, 2020Cell Biology

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

A. Vogel, I. Kanevsky, Y. Che, K. Swanson, A. Muik, M. Vormehr, L. Kranz, K. Walzer, S. Hein, A. Gueler, J. Loschko, M. Maddur, K. Tompkins, J. Cole, B. G. Lui, , Ciolin

This paper reports on a prefusion SARS-CoV-2 spike RNA vaccine that induces strong immune responses and prevents lung infection in non-human primates.

bioRxiv · Sep 8, 2020 · PreprintImmunology