S. Oka

Discovering cancer stem-like cells using Spatial transcriptomic analysis: Nuclear factor I X as a novel therapeutic target for gastric cancer

This study identifies NFIX as a critical regulator of cancer stemness in gastric cancer using spatial transcriptomic analysis and shows its correlation with poor prognosis.

CD34-positive monocytes are highly susceptible to HIV-1

This study identifies CD34+ monocytes as highly susceptible to HIV-1 infection, showing they harbor more proviral DNA and express higher HIV-1 receptors despite cART.

Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia

This study identifies EP4 and fibulin-1 as key regulators of vascular intimal hyperplasia through VSMC proliferation, suggesting EP4 antagonists or fibulin-1 downregulation as potential therapeutic strategies.

Inhibitors of cannabinoid receptor 1 suppress the cellular entry of Lujo virus

This study identifies CB1 receptor antagonists as inhibitors of Lujo virus entry by suppressing viral membrane fusion and reducing infectivity in vitro.

ADP-ribose-acceptor hydrolase 2 (Arh2) deficiency results in cardiac dysfunction, tumorigenesis, inflammation, and decreased survival

This study shows that Arh2 deficiency leads to cardiac dysfunction, tumorigenesis, inflammation, and reduced survival in mice.

Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

The paper analyzes the gut virome in a large cohort, identifying factors influencing virome diversity and its relationship with host and environmental variables.

Celsr1 and CAMSAP3 differently regulate intercellular and intracellular cilia orientation in oviduct multiciliated cells

This study shows Celsr1 and CAMSAP3 regulate BB orientation in MCCs differently, with CAMSAP3 critical for intracellular coordination and Celsr1 dispensable for individual cell orientation.

Higher seroprevalence of Entamoeba histolytica than that of HIV-1 at a voluntary counselling and testing centre in Tokyo

The paper reports higher seroprevalence of Entamoeba histolytica compared to HIV-1 and syphilis in a Tokyo VCT center, with risk factors including male sex, older age, and syphilis positivity.