Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis
C. L. C. Gudd, S. R. Atkinson, E. Mitchell, M.-A. Mawhin, S. Turajlic, J. Larkin, M. R. Thursz, R. D. Goldin, N. Powell, C. G. Antoniades, K. J. Woollard, L. A. Possamai, E. Triantafyllou
This paper develops a mouse model to study CPI-hepatitis and shows that inhibiting CCR2+ monocyte recruitment prevents liver damage caused by checkpoint inhibitors.
bioRxiv · Aug 14, 2023Immunology