This paper investigates compounds that inhibit both Liberibacter asiaticus and Diaphorina citri, proposing a dual-action strategy to combat citrus greening.

bioRxiv · Feb 7, 2022 · PreprintPlant Biology

Hibernation slows epigenetic aging in yellow-bellied marmots

G. M. Pinho, J. G. A. Martin, C. Farrell, A. Haghani, J. A. Zoller, J. Zhang, S. Snir, M. Pellegrini, R. K. Wayne, D. T. Blumstein, S. Horvath

This study examines how hibernation affects epigenetic aging in yellow-bellied marmots using epigenetic clocks and pacemakers, finding that aging slows during hibernation.

bioRxiv · Mar 7, 2021 · PreprintEvolutionary Biology

A Homogeneous SIRPα-CD47 Cell-Based, Ligand-Binding Assay: Utility for Small Molecule Drug Development in Immuno-oncology.

T. Burgess, J. Amason, J. Rubin, D. Duveau, L. Lamy, D. Roberts, C. Farrell, J. Inglese, C. Thomas, T. W. Miller

This paper develops a cell-based ligand-binding assay to identify small molecule inhibitors of the SIRP-CD47 interaction for immuno-oncology drug development.

bioRxiv · Dec 5, 2019Immunology

Multi-plane Imaging of Neural Activity From the Mammalian Brain Using a Fast-switching Liquid Crystal Spatial Light Modulator

R. Liu, N. Ball, J. Brockill, L. Kuan, D. Millman, C. White, A. Leon, D. Williams, S. Nishiwaki, S. de Vries, J. Larkin, D. Sullivan, C. Slaughterbeck, C. Farrell, P. Saggau

The paper introduces a new two-photon microscope using a liquid crystal spatial light modulator to record neural activity in awake mice, finding heterogeneous responses in excitatory neurons across cortical layers.

bioRxiv · Dec 30, 2018Bioengineering