E. Lim

Tempo and mode of evolution across multiple traits in an adaptive radiation of birds (Vangidae)

This study examines the tempo and mode of trait evolution in Malagasy vangas and their relatives, finding that diversification accelerated after arrival in Madagascar due to key innovations in foraging and morphology.

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

Treatment with anti-inflammatory viral serpin modulates immuno-thrombotic responses and improves outcomes in SARS-CoV-2 infected mice

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

PLURIPOTENT STEM CELL-DERIVED CARDIOVASCULAR PROGENITORS DIFFFERENTIATED ON LAMININ 221 REGENERATE AND IMPROVE FUNCTION OF INFARCTED SWINE HEARTS

This paper differentiates pluripotent stem cells into cardiovascular progenitors on laminin 221 and shows improved heart function in infarcted pigs.

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

The paper shows that IDH mutations other than p.R132H in 1p/19q non-codeleted astrocytomas are linked to higher DNA methylation and better patient survival.

VGLL1 drives therapy resistance in estrogen receptor positive breast cancer

This study identifies VGLL1 as a driver of resistance to endocrine therapy in ER+ breast cancer and shows that targeting VGLL1/TEAD interaction can inhibit resistant cell growth.

Lipidomic Profiling Reveals an Age-Related Deficiency of Skeletal Muscle Proresolving Mediators that Contributes to Maladaptive Tissue Remodeling

This study identifies age-related deficiencies in proresolving mediators in skeletal muscle, leading to impaired regeneration and inflammation, and shows that RvD1 treatment can mitigate some adverse effects.

Immunoresolvents Support Skeletal Myofiber Regeneration via Actions on Myeloid and Muscle Stem Cells

This study shows that resolvin D1 promotes skeletal muscle regeneration by modulating myeloid cells and muscle stem cells, improving recovery without directly affecting myogenesis.

MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer.

This study evaluates MDM2 inhibition combined with endocrine therapy and CDK4/6 inhibition in ER-positive breast cancer, showing synergistic anti-tumor effects in resistant models.

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

Cyclin E1 protein is stabilized in BRCA1 mutated breast cancers leading to synergy between CDK2 and PARP inhibitors

The paper identifies cyclin E1 stabilization in BRCA1-mutated breast cancers and shows synergy between CDK2 and PARP inhibitors in treating these cancers.

Escape from nonsense mediated decay associates with anti-tumor immunogenicity

This study identifies NMD-escape fs-indels as a biomarker associated with improved response to immunotherapy in melanoma patients.

Artificial intelligence method to design and fold alpha-helical structural proteins from the primary amino acid sequence

This paper introduces an AI model to design and fold alpha-helical proteins from amino acid sequences, achieving high accuracy and efficiency.

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.