Author

F. Bednar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Organism:mouse· 5 Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cell-cell communication· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2

Frequent Co-Authors

W. Du· 4 shared Y. Zhang· 4 shared F. Lima· 3 shared K. L. Donahue· 3 shared M. Pasca Di Magliano· 3 shared N. G. Steele· 3 shared R. E. Menjivar· 3 shared W. Yan· 3 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

W. Du

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

ROR2 regulates cellular plasticity in pancreatic neoplasia and adenocarcinoma

S. Benitz, A. Steep, M. Nasser, J. Preall, U. M. Mahajan, H. McQuithey, I. Loveless, E. T. Davis, H.-J. Wen, D. W. Long, T. Metzler, S. Zwernik, M. Louw, D. Rempinski, D. Salas-Escabillas, , H. C. Crawford

This study identifies ROR2 as a regulator of cellular plasticity in pancreatic neoplasia, showing it promotes an aggressive PDAC phenotype and resistance to KRAS inhibitors.

bioRxiv · Dec 13, 2023Cancer Biology

Mouse models for pancreatic ductal adenocarcinoma are affected by the cre-driver used to promote KRASG12D activation.

F. Mousavi, J. Thompson, J. Lau, N. Renollet, M. B. Martin, J. McGue, T. Frankel, P. Shooshtari, C. L. Pin, F. Bednar

This study compares mouse models of pancreatic ductal adenocarcinoma driven by different cre-recombinase systems, finding differences in tumor development and inflammation.

bioRxiv · Sep 12, 2023 · PreprintCancer Biology

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

E. S. Carpenter, A. M. Elhossiny, P. Kadiyala, J. Li, J. McGue, B. Griffith, Y. Zhang, J. Edwards, S. Nelson, F. Lima, K. L. Donahue, W. Du, A. C. Bischoff, D. Alomari, H. Watkoske, , M. Pasca Di Magliano

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

bioRxiv · Jan 13, 2023 · PreprintCancer Biology

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

W. Yan, N. G. Steele, S. B. Kemp, R. E. Menjivar, W. Du, E. S. Carpenter, K. L. Donahue, K. L. Brown, V. Irizarry-Negron, S. Yang, W. R. Burns, Y. Zhang, M. Pasca di Magliano, F. Bednar

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

bioRxiv · Jan 11, 2023Cancer Biology

Arginase 1 is a key driver of immune suppression in pancreatic cancer

R. E. Menjivar, Z. C. Nwosu, W. Du, K. Donahue, C. Espinoza, K. Brown, A. Velez, W. Yan, F. Lima, A. Bischoff, P. Kadiyala, D. Salas-Escabillas, C. J. Halbrook, F. Bednar, E. Carpenter, , M. di Magliano

This study shows that Arginase 1 suppresses immune responses in pancreatic cancer by inhibiting T cell activation, and targeting it enhances immunotherapy effectiveness.

bioRxiv · Jun 21, 2022Cancer Biology

Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming.

A. Velez-Delgado, K. L. Donahue, K. L. Brown, W. Du, V. Irizarry-Negron, R. E. Menjivar, E. L. Lasse-Opsahl, N. G. Steele, S. The, J. Lazarus, V. R. Sirihorachai, W. Yan, S. B. Kemp, S. A. Kerk, M. Bollamplly, , M. Pasca di Magliano

This study shows that extrinsic KRAS signaling reprograms pancreatic fibroblasts to create an inflammatory microenvironment that supports tumor growth.

bioRxiv · Aug 26, 2021Cancer Biology