HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification
N. E. Sapp, N. Burge, K. Cox, S. Thapa, P. Prakash, M. Balasubramaniam, D. Christensen, M. Li, J. Linderberger, M. Kvaratskhelia, W. I. Sundquist, J. Pandhare, R. Craigie, M. G. Poirier, C. Dash
This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.
bioRxiv · Feb 16, 2022 · PreprintBiochemistry