C. Evans

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Wheat NAC transcription factor NAC5-1 is a positive regulator of senescence

This study identifies NAC5-1 as a positive regulator of leaf senescence in wheat and shows its effects on senescence timing through mutation and overexpression experiments.

SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous system

This study shows SARS-CoV-2 can infect neurons, astrocytes, choroid plexus epithelial cells, and pericytes in the human central nervous system, supporting a model of direct viral infection as a cause of neurological symptoms in COVID-19.

Transglobal spread of an ecologically significant sea urchin parasite

The paper identifies a Philaster sp. parasite responsible for mass mortality of sea urchins across the Caribbean and Mediterranean, showing its rapid global spread and potential for long-range transmission.

Assessing generalizability of a dengue classifier across multiple datasets

This study evaluates the generalizability of a dengue classifier across multiple datasets, finding that logistic regression models perform well but require adjustments for new populations.

A network medicine approach to elucidate mechanisms underlying menopause-induced knee osteoarthritis

This study identifies menopause-induced cartilage degradation, senescence, and extracellular matrix disassembly, and suggests hormone therapy or senolytics may mitigate these effects.

Sexual and temporal variation in New Zealand bellbird song repertoires

This study examines sex and temporal variation in New Zealand bellbird song repertoires, finding males have more syllable types than females, but both show similar temporal changes.

The molecular and metabolic program for adaptation of white adipocytesto cool physiologic temperatures

This study investigates how white adipocytes adapt to cooler temperatures, finding changes in gene expression, lipid metabolism, and energy source utilization.

Seminal fluid protein divergence among populations exhibiting postmating prezygotic reproductive isolation

This study identifies divergent seminal fluid proteins between Drosophila montana populations showing postmating prezygotic isolation, revealing their potential role in reproductive isolation.

Autoantibody landscape of advanced prostate cancer

This study characterizes the autoantibody landscape in metastatic castration-resistant prostate cancer using serum epitope repertoire analysis and identifies novel tumor-specific epitopes.

Bioengineering a novel 3D in-vitro model to recreate physiological oxygen levels and tumor-immune interactions

This study develops a 3D in vitro model (3D-O) that mimics physiological oxygen levels in breast cancer, showing hypoxia-induced changes that promote immune evasion and reduced CD8+ T cell infiltration.

The genome-wide transcriptional response to varying RpoS levels in Escherichia coli K-12

This study examines how varying RpoS levels affect the transcriptome of E. coli during stationary phase, identifying gene regulation patterns and promoter sensitivity mechanisms.