Author

J. Michaelis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:fluorescence / live-cell microscopy· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Approach:microscopy & imaging analysis· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Sefer· 2 shared L. Streit· 2 shared T. Vomhof· 2 shared A. Barth· 1 shared A. C. Ludolph· 1 shared A. Hartmann· 1 shared A. Kapanidis· 1 shared B. Ambrose· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

A. Sefer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

G. Agam, C. Gebhardt, M. Popara, R. Maechtel, J. Folz, B. Ambrose, N. Chamachi, S. Y. Chung, T. D. Craggs, M. de Boer, D. Grohmann, T. Ha, A. Hartmann, J. Hendrix, V. Hirschfeld, , T. Cordes

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

bioRxiv · Aug 3, 2022Biophysics

Stress induced TDP-43 mobility loss independent of stress granules

L. Streit, T. Kuhn, T. Vomhof, A. C. Ludolph, J. H. Weishaupt, J. C. M. Gebhardt, J. Michaelis, K. M. Danzer

The paper investigates TDP-43 mobility under stress and recovery, finding stress-induced mobility loss in cytoplasm and nucleus, independent of stress granules.

bioRxiv · Feb 28, 2022Biophysics

Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level

A. Sefer, E. Kallis, T. Eilert, C. Roecker, D. Neuhaus, S. Eustermann, J. Michaelis

This study investigates how PARP-1 senses DNA single-strand breaks at the single-molecule level, revealing an induced fit mechanism involving multi-domain assembly and inhibitor effects.

bioRxiv · Feb 26, 2022Biophysics

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance

T. Phan, P. Maity, C. Ludwig, L. Streit, J. Michaelis, K. Scharffetter-Kochanek, S. Iben

This study identifies TFIIE's role in ribosomal RNA synthesis and shows that mutations impair ribosomal biogenesis, leading to proteostasis loss and TTD symptoms.

bioRxiv · Dec 16, 2020Cell Biology

Artifact Formation in Single Molecule Localization Microscopy

J. M. Reichel, T. Vomhof, J. Michaelis

The paper examines image artifacts in single molecule localization microscopy (SMLM) under low localization accuracy and presents a new software tool, FIRESTORM, optimized for high accuracy reconstruction.

bioRxiv · Jul 12, 2019 · PreprintBiophysics