Author

T. Phan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 2 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. S. Perelson· 2 shared J. Z. Li· 2 shared R. Ke· 2 shared R. M. Ribeiro· 2 shared A. Bah· 1 shared A. Duenkler· 1 shared A. E. S. Barentine· 1 shared A. Fallatah· 1 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersImmunology

A. S. Perelson

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Stabilized dengue virus 2 envelope subunit vaccine redirects the neutralizing antibody response to all E-domains

D. J. Thiono, D. L. Samaras, T. Phan, D. R. Zhu, R. P. Shah, I. N. Castillo, L. J. Forsberg, L. Premkumar, R. S. Baric, S. Tian, B. Kuhlman, A. M. de Silva

This study evaluates a stabilized DENV2 E homodimer vaccine, finding it elicits broader neutralizing antibody responses targeting multiple E protein domains compared to the wild-type monomer.

bioRxiv · Jul 18, 2024Microbiology

Understanding early HIV-1 rebound dynamics following antiretroviral therapy interruption: The importance of effector cell expansion

A. S. Perelson, T. Phan, J. M. Conway, N. Pagane, J. Kreig, N. Sambaturu, S. Iyaniwura, J. Z. Li, R. M. Ribeiro, R. Ke

The paper uses dynamic models to analyze viral rebound after HIV-1 treatment interruption, showing effector cell expansion rate distinguishes post-treatment controllers from non-controllers.

bioRxiv · May 3, 2024Immunology

Uncovering the molecular interactions underlying MBD2 and MBD3 phase separation

M. Nicole, T. Phan, J. L. Henty-Ridilla, Y. C. Kim, J. Mittal, A. Bah

This study investigates the molecular interactions driving phase separation in MBD2 and MBD3 proteins, revealing distinct mechanisms despite their structural similarity.

bioRxiv · Apr 29, 2024Biochemistry

Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody

T. Phan, C. Zitzmann, K. W. Chew, D. M. Smith, E. S. Daar, D. A. Wohl, J. J. Eron, J. S. Currier, M. D. Hughes, M. C. Choudhary, R. Deo, J. Z. Li, R. M. Ribeiro, R. Ke, A. S. Perelson

This paper models viral resistance emergence in SARS-CoV-2 treated with anti-spike monoclonal antibodies, showing that target cell replenishment mechanisms can explain high viral rebounds.

bioRxiv · Sep 14, 2023Immunology

An Integrated Platform for High-Throughput Nanoscopy

A. E. S. Barentine, Y. Lin, E. M. Courvan, P. Kidd, M. Liu, L. Balduf, T. Phan, F. Rivera-Molina, M. R. Grace, Z. Marin, M. Lessard, J. Rios-Chen, S. Wang, K. M. Neugebauer, J. Bewersdorf, D. Baddeley

This paper presents an integrated platform for high-throughput single-molecule localization microscopy (SMLM) that enables imaging of 10,000 cells per day.

bioRxiv · Apr 20, 2022Biophysics

Nucleolar TFIIE plays a role in ribosomal biogenesis and performance

T. Phan, P. Maity, C. Ludwig, L. Streit, J. Michaelis, K. Scharffetter-Kochanek, S. Iben

This study identifies TFIIE's role in ribosomal RNA synthesis and shows that mutations impair ribosomal biogenesis, leading to proteostasis loss and TTD symptoms.

bioRxiv · Dec 16, 2020Cell Biology

Keratin 19 maintains E-cadherin localization at the cell surface and stabilizes cell-cell adhesion of MCF7 cells

S. Alsharif, P. Sharma, K. Bursch, R. Milliken, M. Collins, V. Lam, A. Fallatah, T. Phan, P. Dohlman, G. Nehmetallah, C. B. Raub, B. M. Chung

This study shows that keratin 19 maintains E-cadherin at the cell surface, stabilizes cell-cell adhesion, and influences migration and colony formation in MCF7 cells.

bioRxiv · May 28, 2020Cell Biology

The Cell Polarity Proteins Boi1p And Boi2p Stimulate Vesicle Fusion At The Plasma Membrane Of Yeast Cells

J. Kustermann, Y. Wu, L. Rieger, D. Dedden, T. Phan, P. Walther, A. Duenkler, N. Johnsson

The paper identifies Boi1p and Boi2p as essential proteins that mediate vesicle fusion and Cdc42p activation during yeast polar growth.

bioRxiv · May 31, 2017Cell Biology