Author

V. Jayaraman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Immunology· 2 Animal Behavior & Cognition· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Approach:comparative / phylogenetic analysis· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

H. Balaram· 3 shared A. Bellur· 2 shared A. Suryavanshi· 2 shared A. D. Adamson· 1 shared A. K. Pandey· 1 shared A. K. Vadakkepat· 1 shared A. Krishnamoorti· 1 shared A. M. Romero· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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3 shared papersBiochemistry

H. Balaram

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Author profile →

10 papers

Recent·Most cited

Allosteric Competition and Inhibition in AMPA Receptors

W. D. Hale, A. M. Romero, C. U. Gonzalez, V. Jayaraman, A. Y. Lau, R. L. Huganir, E. C. Twomey

This study reveals how negative allosteric modulators inhibit AMPA receptors by disrupting glutamate binding and outcompeting positive modulators, offering insights for therapeutic design.

bioRxiv · Nov 28, 2023Biophysics

CD163 and Tim-4 identify resident intestinal macrophages across sub-tissular regions that are spatially regulated by TGF-β

I. E. Prise, V. Jayaraman, V. Kästele, R. H. Daw, K. Wemyss, H. Bridgeman, S. Tamburrano, P. Strangward, C. Chew, L. Martens, C. L. Scott, M. Guilliams, A. D. Adamson, J. E. Konkel, T. N. Shaw, J. R. Grainger

The paper identifies CD163 and Tim-4 as markers for intestinal macrophages and shows TGF-β regulates their spatial distribution in different niches.

bioRxiv · Aug 21, 2023Immunology

Enantioselectivity in the Enzymatic Dehydration of Malate and Tartrate: Mirror Image Specificities of Structurally Similar Dehydratases

A. Bellur, S. Mukherjee, P. Sharma, V. Jayaraman, H. Balaram

This study investigates the enantiomer-specificity of two structurally similar enzymes, FH and L-TTD, revealing evolutionary divergence in their substrate stereospecificity preferences.

bioRxiv · Jun 17, 2023Biochemistry

A comparative study of low-pH tolerance and chitinase activity between toxigenic and non-toxigenic strains of Vibrio cholerae

V. Jayaraman, S. A. Khan, K. Perinbam, I. Rakheja, A. K. Vadakkepat, S. K. Chaudhary, A. K. Pandey, J. Mitra

This study compares low-pH tolerance and chitinase activity between toxigenic and non-toxigenic Vibrio cholerae strains, finding that the non-toxigenic strain exhibits greater growth and chitinase activity under acidic conditions.

bioRxiv · Feb 13, 2023 · PreprintMicrobiology

Evaluation of Renal Markers in Systemic Autoimmune Diseases

H. Krishnamurthy, Y. Yang, Q. Song, K. Krishna, V. Jayaraman, T. Wang, K. Bei, J. J. Rajasekaran

This study examines renal markers in autoimmune diseases, finding that autoantibodies significantly affect marker levels and are more frequent in severe renal damage.

bioRxiv · Nov 17, 2022Immunology

Revisiting the burden borne by fumarase: enzymatic hydration of an olefin

A. Bellur, S. Das, V. Jayaraman, S. Behera, A. Suryavanshi, S. Balasubramanian, P. Balaram, G. Jindal, H. Balaram

This study investigates the catalytic mechanism of class-I fumarate hydratase by analyzing structural and computational data from Methanocaldococcus jannaschii and Leishmania major enzymes.

bioRxiv · Sep 3, 2022Biochemistry

A counter-enzyme complex regulates glutamate metabolism in Bacillus subtilis

V. Jayaraman, D. J. Lee, N. Elad, S. Vimer, M. Sharon, J. S. Fraser, D. S. Tawfik

The paper identifies a counter-enzyme complex in Bacillus subtilis that regulates glutamate metabolism by inhibiting GudB activity, essential for growth under varying glutamate conditions.

bioRxiv · Apr 12, 2021Biochemistry

Single-molecule FRET monitors CLC transporter conformation and subunit independence

R. C. Cheng, A. Krishnamoorti, V. Berka, R. J. Durham, V. Jayaraman, M. Maduke

This study uses smFRET to monitor CLC-ec1 conformational changes and shows subunit independence in transport.

bioRxiv · Sep 7, 2020 · PreprintBiophysics

On the adaptive behavior of head-fixed flies navigating in two-dimensional, visual virtual reality

H. Haberkern, M. A. Basnak, B. Ahanonu, D. Schauder, J. D. Cohen, M. Bolstad, C. Bruns, V. Jayaraman

This study shows that head-fixed flies navigate differently in 2D visual VR compared to 1D VR, adapting behavior to optogenetic stimuli and learning to avoid specific landmarks.

bioRxiv · Nov 4, 2018Animal Behavior & Cognition

Biochemical characterization and essentiality of Plasmodium fumarate hydratase

V. Jayaraman, A. Suryavanshi, P. Kalale, J. Kunala, H. Balaram

The paper characterizes Plasmodium fumarate hydratase, identifies its inhibitor, and shows mouse-strain dependent essentiality of the gene.

bioRxiv · Sep 5, 2017Biochemistry