Y. Harada

Raman microscopy of cryofixed biological specimens for high-resolution and high-sensitivity chemical imaging

This study improves Raman microscopy's signal-to-noise ratio and resolution by imaging cryofixed biological specimens, enabling high-content chemical imaging under physiological conditions.

Time-deterministic cryo-optical microscopy

The paper introduces a technique to rapidly freeze biological systems during optical observation, enabling detailed time-specific analysis of cellular dynamics at high spatial resolution.

Inhibition of the BMP pathway suppresses tumor growth via downregulation of EGFR in MEK/ERK-dependent colorectal cancer

This study shows that inhibiting the BMP pathway suppresses colorectal cancer growth by reducing EGFR, and combining BMP and MEK inhibition enhances therapeutic effects in patient-derived organoids.

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

Photothermal Dye-based Subcellular-sized Heat Spot Enabling the Modulation of Local Cellular Activities

The paper introduces nanoHT, a photothermal nanoparticle that creates subcellular heat spots to modulate cellular activities, inducing cell death and muscle contraction in specific areas.

The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins

This study shows that FUT8 regulates mucin secretion and viscoelastic properties, linking its dysfunction to ulcerative colitis pathogenesis.

An improved molecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under pathological conditions.

Heat hypersensitivity of ryanodine receptor type 1 mutants implicated in malignant hyperthermia

The paper shows that heat hypersensitive RyR1 mutants cause heat-induced Ca2+ release, contributing to malignant hyperthermia through a positive feedback loop.

In situ measurement of intracellular thermal conductivity using heater-thermometer hybrid diamond nanosensor

The paper measures intracellular thermal conductivity in HeLa cells using a hybrid diamond nanosensor, finding a mean value of 0.11 Wm-1K-1 with 40% variation.

Homologous expression and characterization of gassericin T and gassericin S, a novel class IIb bacteriocin produced by Lactobacillus gasseri LA327

This study identifies and characterizes gassericin S, a novel class IIb bacteriocin produced by Lactobacillus gasseri LA327, and demonstrates its activity and stability.