Y. Ohkawa

The paper identifies importin α as a marker of a distinct micronuclear environment in cancer cells, associated with genomic instability and immune evasion.

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

This study identifies Atf3 as a key regulator of transition from compensation to dysfunction in female mitochondrial cardiomyopathy using single-cell transcriptomics.

This study shows that trifluridine induces aberrant mitosis and cytotoxicity in both p53-null and p53-GOF mutant cells, independent of p53 function.

This study shows that excess mannose causes dNTP depletion, leading to genomic instability and enhanced sensitivity to chemotherapy in cancer cells.

This study shows that nucleoporin fusions form phase-separated nuclear bodies that enhance gene activation by condensing MLL1 and CRM1 at target loci.

This study shows that FUT8 regulates mucin secretion and viscoelastic properties, linking its dysfunction to ulcerative colitis pathogenesis.

This study investigates MCM hexamer states during the cell cycle in human cells and links their formation to histone H4K20 methylation levels, showing that di/trimethyl-H4K20 correlates with double MCM hexamer formation.

The paper develops a genetically encoded probe to detect elongating RNA polymerase II in living cells and shows its foci move more dynamically than chromatin domains.

The paper develops a method to study histone variant incorporation and finds that chromatin structure and DNA replication influence histone deposition patterns.

The paper identifies genomic regions associated with PML bodies and shows their role in maintaining hypo-methylated states at Y-linked gene promoters through DNMT3A exclusion.

The paper shows that cell competition corrects noisy Wnt/β-catenin gradients by eliminating unfit cells, ensuring robust embryonic patterning.