J. R. Williamson

The paper investigates proteome remodeling in bacterial lineages over 40,000 generations and identifies sector-specific adaptations in metabolic enzyme expression.

The paper uses mass photometry to study HIV-1 Gag assembly with vRNA on lipid membranes, showing trimerization and gradual hexamer formation.

The paper reports the assembly of 50S ribosome intermediates using in vitro reconstitution and cryo-EM, revealing parallel assembly pathways and cooperative blocks.

The paper uses cryo-EM and a new segmentation method to reveal the early assembly pathway of bacterial ribosome large subunit, identifying cooperative blocks and a unified maturation landscape.

The paper identifies a metabolic sum rule in bacteria showing that exogenous metabolite accumulation depletes endogenous metabolites, causing growth reduction, and demonstrates how cells mitigate this by acidifying their cytoplasm.

The paper shows the pre-B cell receptor changes Galectin-1's binding specificity from exo- to endo-type, promoting pre-B cell survival.

The paper develops a workflow to quantitatively analyze structural heterogeneity in cryo-EM datasets, applied to E. coli ribosome assembly intermediates to identify new branch points and interactions.