M. Scott

Retrospective Analysis of the Effects of BWF Interdisciplinary Postdoctoral to Faculty Transition Awards on Future Funding Success

The paper evaluates the impact of the BWF CASI award on future funding success, finding higher grant rates and dollars for recipients compared to unsuccessful applicants and K99/R00 recipients.

Duration of Morning Hyperinsulinemia Determines Hepatic Glucose Uptake and Glycogen Storage Later in the Day

The study shows that prolonged morning hyperinsulinemia improves hepatic glucose uptake and glycogen storage during an afternoon clamp compared to shorter, higher-rate insulin delivery.

Four centuries of commercial whaling eroded 11,000 years of population stability in bowhead whales

This study uses fossil data and modeling to show that commercial whaling caused genetic diversity loss in bowhead whales, threatening their resilience to future climate change.

Leucine Rich Repeat Kinase 2 is not required for lysozyme expression in intestinal Paneth cells

The paper investigates the role of LRRK2 in lysozyme expression in Paneth cells and finds that LRRK2 is not required for lysozyme expression in the murine gut and is not expressed in Paneth cells.

Proteome partitioning constraints on long-term laboratory evolution

The paper investigates proteome remodeling in bacterial lineages over 40,000 generations and identifies sector-specific adaptations in metabolic enzyme expression.

Functional characterization of a PHF8 processed pseudogene in the mouse genome

The paper identifies a functional PHF8 pseudogene in mice that produces a cytoplasmic protein with distinct molecular functions compared to the parental Phf8 protein.

Impact of Holocene environmental change on the evolutionary ecology of an Arctic top predator

This study examines how Holocene environmental changes impacted the evolutionary ecology of Greenlandic polar bears using genomics, isotopic analysis, morphometrics, and ecological modeling.

Polyploidy, regular patterning of genome copies, and unusual control of DNA partitioning in the Lyme disease spirochete

This study shows that Borrelia burgdorferi is polyploid in culture and ticks, with regular genome copy spacing controlled by ParA/ParZ and ParB/SMC systems.

Growth-dependent heterogeneity in the DNA damage response in Escherichia coli

This study shows that in E. coli, slow growth leads to more cells with high SOS response activation despite faster SOS induction in fast growth.

A CRISPR interference platform for selective downregulation of gene expression in Borrelia burgdorferi

This paper develops a CRISPR interference platform for efficient gene downregulation in Borrelia burgdorferi, demonstrating >95% repression efficiency for multiple genes and revealing roles in motility and cell division.

Comparative analysis of genome-wide DNA methylation identifies patterns that associate with conserved transcriptional programs in osteosarcoma

This study identifies DNA methylation patterns in human and canine osteosarcoma samples that correlate with conserved transcriptional programs and tumor states, not cell composition.

Characterization of fluorescent proteins, promoters, and selectable markers for applications in the Lyme disease spirochete Borrelia burgdorferi

The paper develops and characterizes fluorescent proteins, antibiotic selection markers, and promoters for use in Borrelia burgdorferi to enhance genetic tools and study its biology.