Author

J. Schwartz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:E. coli· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

C. Brugger· 2 shared A. Deaconescu· 1 shared A. K. Chopra· 1 shared A. M. Deaconescu· 1 shared A. Rajagopal· 1 shared A. Sulakvelidze· 1 shared A. W. Bisson Filho· 1 shared B. H. Neil· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersBiophysics

C. Brugger

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Bacteriophage Cocktail Targeting Yersinia pestis Provides Strong Post-Exposure Protection in a Rat Pneumonic Plague Model

P. B. Kilgore, J. Sha, E. Hendrix, B. H. Neil, W. S. Lawrence, J. Peel, L. Hittle, J. Woolston, A. Sulakvelidze, J. Schwartz, A. K. Chopra

This paper evaluates a bacteriophage cocktail, YPP-401, for post-exposure protection against pneumonic plague in rats, showing ~88% protection when administered intranasally or intraperitoneally 18 hours post-exposure.

bioRxiv · Jan 17, 2024 · PreprintMicrobiology

AAV-mediated Delivery of Plakophilin-2a Arrests Progression of Arrhythmogenic Right Ventricular Cardiomyopathy in Murine Hearts: Preclinical Evidence Supporting Gene Therapy in Humans

C. J. van Opbergen, B. Narayanan, C. B. Sacramento, K. M. Stiles, V. Mishra, E. Frenk, D. Ricks, G. Chen, M. Zhang, P. Yarabe, J. Schwartz, M. Delmar, C. D. Herzog, M. Cerrone

This paper demonstrates that AAV-mediated delivery of PKP2a gene therapy arrests ARVC progression and prolongs survival in PKP2-deficient mice.

bioRxiv · Jul 12, 2023Physiology

A rapid, multiplex digital PCR assay for EGFR, KRAS, BRAF, ERBB2 variants and ALK, RET, ROS1, NTRK1 gene fusions in non-small cell lung cancer

B. Leatham, K. McNall, H. K. Subramanian, L. Jacky, J. G. Alvarado, D. Yurk, M. Wang, D. C. Green, G. J. Tsongalis, A. Rajagopal, J. Schwartz

The paper describes a multiplex digital PCR assay for detecting genetic variants and fusions in NSCLC, showing high accuracy and utility in challenging samples.

bioRxiv · Mar 9, 2023 · PreprintCancer Biology

Structure of Phosphorylated-like ClpXP Adaptor RssB Reveals an Interface Switch for Activation

C. Brugger, J. Schwartz, M. Filipovski, A. M. Deaconescu

The paper presents the crystal structure of phosphorylated-like RssB adaptor bound to ClpXP, revealing conformational changes that enable activation through domain rearrangement.

bioRxiv · Dec 15, 2022 · PreprintBiophysics

Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB

J. Schwartz, J. Son, C. Brugger, A. Deaconescu

This study reports crystal structures of RssB's receiver domain in unphosphorylated and phosphomimic forms, revealing structural differences and suggesting a novel signaling mechanism in E. coli's stress response.

bioRxiv · Jan 11, 2021Biophysics

Haloferax volcanii immersed liquid biofilms develop independently of known biofilm machineries and exhibit rapid honeycomb pattern formation

H. Schiller, S. Schulze, Z. Mutan, C. de Vaulx, C. Runcie, J. Schwartz, T. Rados, A. W. Bisson Filho, M. Pohlschroder

mSphere · Dec 23, 2020Peer-reviewedMicrobiology