The crystal and cryo-EM structures of PLCγ2 reveal dynamic inter-domain recognitions in autoinhibition
Y.-C. Shin, A. M. Plummer-Medeiros, A. Mungenast, H.-w. Choi, K. TenDyke, X. Zhu, J. Shepard, N. Zhuang, L. Hu, D. Qian, K. Song, C. Xu, J. Wang, S. B. Poda, M. Liao, Y. Chen
The paper determines crystal and cryo-EM structures of PLCγ2 in autoinhibited states and bound to FGFR1 kinase domain, revealing dynamic inter-domain interactions in autoinhibition.
bioRxiv · Sep 7, 2023 · PreprintBiochemistry