J. Chan

MAGNETICALLY STEERED CELL THERAPY FOR REDUCTION OF INTRAOCULAR PRESSURE AS A TREATMENT STRATEGY FOR OPEN-ANGLE GLAUCOMA

A magnetic cell therapy reduced intraocular pressure in a glaucoma mouse model, with hAMSCs showing greater efficacy than iPSC-TM cells.

Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer

The paper identifies ATOH1 as a pro-metastatic oncogenic driver in SCLC by showing its role in cell survival and metastasis suppression upon depletion.

Maternal Under-Nutrition During Pregnancy Alters the Molecular Response to Over-Nutrition in Multiple Organs and Tissues in Juvenile Offspring

This study shows that maternal undernutrition during pregnancy alters the molecular response to overnutrition in juvenile offspring, increasing risk of metabolic diseases.

Background matching can reduce responsiveness of jumping spiders to stimuli in motion

This study shows that jumping spiders are less responsive to camouflaged moving stimuli than to conspicuous ones, with smaller and faster stimuli being less detectable.

Pan-cancer analysis of the ion permeome reveals functional regulators of glioblastoma aggression

The paper identifies survival-associated ion permeome genes across 29 cancer types and shows their role in glioblastoma aggression through functional experiments.

Benchmark of force fields to characterize the intrinsically disordered R2-FUS-LC region

The paper benchmarks thirteen force fields to assess their ability to simulate the behavior of the intrinsically disordered R2-FUS-LC region and its aggregation into cross-β amyloid fibrils.

Effects of breast fibroepithelial tumor associated retinoic acid receptor alpha ligand binding domain mutations on receptor function and retinoid signaling

This study examines how mutations in the RAR ligand binding domain affect retinoic acid signaling and tumorigenesis in breast fibroepithelial tumors.

Robust and High-Throughput Analytical Flow Proteomics Analysis of Cynomolgus Monkey and Human Matrices with Zeno SWATH Data Independent Acquisition

This paper develops and benchmarks a high-throughput, robust proteomics method using Zeno SWATH DIA for analyzing cynomolgus monkey and human samples, showing improved sensitivity and coverage for metabolic disease studies.

Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

Development of a Novel Air-Liquid Interface Airway Tissue Equivalent Model for In Vitro Respiratory Modeling Studies

This study develops a 3D airway tissue equivalent model with native fibroblasts, solubilized ECM, and tunable hydrogel to better mimic human airway biology and assess its impact on epithelial differentiation.

Epidermis derived lactate promotes sterile inflammation by inducing metabolic rewiring in macrophages.

The paper shows that epidermis-derived lactate promotes sterile inflammation by inducing metabolic changes in macrophages that support their effector functions.

HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD

This study shows that HDAC6 inhibitor ACY-1083 protects lung epithelial function in COPD by reducing permeability and cytokine production under various challenges.

Isolation and comparative analysis of antibodies that broadly neutralize sarbecoviruses

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

NMR metabolomics of symbioses between bacterial vaginosis associated bacteria

The paper uses NMR metabolomics to analyze metabolic interactions between bacterial vaginosis-associated bacteria and lactobacilli, revealing how symbiotic relationships influence metabolite availability linked to PTB and inflammation.

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.

Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice

This study shows maternal obesity leads to fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in a sex-dependent manner.

A novel strain of lumpy skin disease virus causes clinical disease in cattle in Hong Kong

This paper reports the first detection of lumpy skin disease virus in Hong Kong, identifying a novel strain genetically distinct from previous outbreaks.

Increased disease burden in Interleukin-3 deficient mice after Mycobacterium tuberculosis and herpes simplex virus infections

This study shows that IL-3 deficiency increases disease severity in mice infected with M. tuberculosis and HSV-1/HSV-2.

macroH2A2 shapes chromatin accessibility at enhancer elements in glioblastoma to modulate a targetable self-renewal epigenetic network

This study identifies macroH2A2 as a regulator of chromatin accessibility at enhancers in glioblastoma, showing that inhibiting Menin increases macroH2A2 and represses self-renewal.

Simultaneous Control of Infection and Inflammation by Keratin-Derived Antimicrobial Peptides (KAMPs) Targeting TLRs and Co-receptors

This study identifies keratin-derived antimicrobial peptides (KAMPs) that simultaneously reduce inflammation and infection by targeting TLRs and co-receptors, offering a dual therapeutic strategy for inflammatory and infectious diseases.

Membrane-proximal external region is a superior target for mediating effector activity of HIV-1 specific chimeric antigen receptor modified T cells.

This paper develops a multicolor flow cytometry assay to compare anti-HIV-1 activity of different CAR constructs and identifies that CARs targeting the membrane-proximal external region show higher cytotoxicity than CD4{zeta} CAR.

Trimester-specific Zika virus infection affects placental responses in women

This study examines how ZIKV infection during different pregnancy trimesters affects placental immune and transcriptomic responses, identifying unique molecular changes associated with early infection.

An efficient timer and sizer of biomacromolecular motions

The paper develops an efficient method to estimate the time scales and sizes of slow protein motions using elastic network models and power laws validated by NMR data.

Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors

This study shows that Capicua regulates neural stem cell proliferation and lineage specification by controlling Ets factors, with implications for oligodendroglioma development.

A Likelihood-Free Inference Framework for Population Genetic Data using Exchangeable Neural Networks

This paper introduces an exchangeable neural network framework for likelihood-free inference in population genetics, demonstrating superior performance on recombination hotspot testing.

Nuclear Abl Drives miR-34c Transfer by Extracellular Vesicles to Induce Radiation Bystander Effects

The paper shows that nuclear Abl drives miR-34c secretion via extracellular vesicles, which induce ROS and DNA damage in non-irradiated cells, causing radiation bystander effects.

Type 2 diabetes promotes cell centrosome amplification and the role of AKT-ROS-dependent signalling of ROCK1 and 14-3-3σ

This study shows type 2 diabetes increases centrosome amplification in PBMCs through AKT-ROS-dependent activation of ROCK1 and 14-3-3σ.