Cancer BiologyCell Death & DiseasePeer-reviewed
Lomitapide, a cholesterol-lowering drug, is an anticancer agent that induces autophagic cell death via inhibiting mTOR
B. Lee, S. J. Park, S. Lee…·S. Kim
This study identifies lomitapide, a cholesterol-lowering drug, as an mTORC1 inhibitor that induces autophagic cell death in cancer cells and enhances immune checkpoint blockade in preclinical models.