Pharmacology & ToxicologybioRxivPreprint
Molecular Mechanisms of Quizartinib Resistance in FLT3 Mutants
D. Zhao, Y. Li, A. Vu…·Jinliang Nan
This study identifies molecular mechanisms of Quizartinib resistance in FLT3 mutants using molecular dynamics simulations and experimental validation, showing distinct electrostatic and hydrophobic effects of D835Y and F691L mutations.
DOI 10.64898/2026.11.09.765260