Reprogramming neuroblastoma by diet-enhanced polyamine depletion
S. Cherkaoui, L. Yang, M. J. McBride, C. Turn, W. Lu, C. Eigenmann, G. E. Allen, O. O. Panasenko, L. Zhang, A. Vu, K. Liu, Y. Li, O. H. Gandhi, L. Surrey, M. Wierer, , R. J. Morscher
This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.
bioRxiv · Jan 7, 2024Cancer Biology