K. Chiba

The chromokinesin Kid (KIF22) forms a homodimer, moves processively along microtubules and transports double-stranded DNA

This study shows that Kid (KIF22) forms a homodimer, moves processively along microtubules, and transports double-stranded DNA, reclassifying it as a processive and dimeric motor.

The FHA domain is essential for the autoinhibition of KIF1A/UNC-104

The paper investigates the role of the FHA domain in regulating dimerization of DmUNC-104 and links abnormal dimerization to human diseases.

Characterizing Human KIF1Bβ Motor Activity by Single-Molecule Motility Assays and Caenorhabtidis elegans Genetics.

This study characterizes KIF1Bβ motor activity using single-molecule assays and C. elegans genetics, showing reduced activity due to a disease mutation.

Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals common and distinct activation mechanisms in kinesin-3

This study compares KLP-6 and UNC-104, two Caenorhabditis elegans kinesin-3 proteins, revealing that autoinhibition release triggers dimerization and processive movement in UNC-104 but not in KLP-6.

Diversification of the recombinant anti-kinesin monoclonal antibody H2

The paper demonstrates that recombinant H2 monoclonal antibody performs equivalently to hybridoma-derived H2 in detecting KHCs and ALS-associated aggregates.

An ALS-associated mutant KIF5A forms oligomers and aggregates and induces neuronal toxicity

This study shows that an ALS-associated KIF5A mutant forms oligomers and aggregates, leading to neuronal toxicity rather than loss of function.

Reconstitution of Kinesin-1 Activation

This study reconstitutes kinesin-1 activation in vitro, revealing that KLC-based inhibition and cargo-adaptor binding regulate motor activity, with a third non-motor MAP required for robust motility.

Combined landscape of single-nucleotide variants and copy-number alterations in clonal hematopoiesis

The paper combines SNVs/indels and CNAs analysis in CH to show their co-occurrence and impact on health outcomes.

POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

A Highly Conserved 310-Helix Within the Kinesin Motor Domain is Critical for Kinesin Function and Human Health.

This study identifies a conserved 310-helix in KIF1A critical for motor function and human health, showing that the P305L mutation disrupts microtubule association and motor performance.

Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors

This study shows that disease-associated KIF1A mutations hyperactivate motor activity, leading to increased anterograde axonal transport of synaptic vesicle precursors and contributing to motor neuron disease.