S. Terada

Non-cell-adhesive hydrogel promotes formation of human blastoid from primed human pluripotent stem cells.

A non-cell-adhesive hydrogel enables blastoid formation from primed hPSC, mimicking blastocyst structure and differentiation.

Generation of iPSCs from endangered Grevy's zebra and comparative transcriptomic analysis of mammalian PSCs

This study generates iPSCs from Grevy's zebra and compares their transcriptome to other mammalian PSCs, revealing evolutionary conservation and species-specific variation in pluripotency genes.

POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

In vitro nonalcoholic fatty liver disease model with cyclo-olefin-polymer-based microphysiological systems

This paper develops a COP-MPS in vitro model to study NAFLD by preventing FFA absorption, showing lipid accumulation and cell inactivation in HepaRG cells.

Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

The paper develops a gut-liver-on-a-chip platform to model NAFLD and shows co-culturing gut and liver cells alters gene expression and lipid accumulation in response to free fatty acids.

Recapitulation of human embryonic heart beating to promote differentiation of hepatic endoderm to hepatoblasts

The paper uses a microfluidic platform to simulate human heart beats, enhancing the functional properties of hepatoblasts derived from hepatic endoderm.

Heat treatment functionalizes hepatocyte-like cells derived from human embryonic stem cells.

This study shows that culturing hepatocyte-like cells from human embryonic stem cells at 39°C improves hepatic functions like albumin secretion and CYP3A4 activity without significant cell death.

Direct synthesis of self-organized blastocyst-like cysts derived from human pluripotent stem cells

The paper describes a method to generate self-organized blastocyst-like cysts from human pluripotent stem cells using a hydrogel matrix and identifies trophoblast and inner cell mass formation.

Three-dimensional cultured Liver-on-a-Chip with mature hepatocyte-like cells derived from human pluripotent stem cells

This paper develops a simple Liver-on-a-Chip platform using hPSC-derived hepatocyte-like cells, showing improved hepatic function and maturation.