H. Ishii

Establishing a method for the cryopreservation of viable peripheral blood mononuclear cells in the International Space Station

This study develops a cryopreservation method for blood cells under ISS constraints, demonstrating viability recovery and subset analysis using flow cytometry.

CD34-positive monocytes are highly susceptible to HIV-1

This study identifies CD34+ monocytes as highly susceptible to HIV-1 infection, showing they harbor more proviral DNA and express higher HIV-1 receptors despite cART.

Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity

This study identifies C15ORF48 as a mitochondrial protein that induces stress-independent autophagy, reducing oxidative stress and autoimmunity in thymic epithelial cells.

Robust capability of renal tubule fatty acid uptake from apical and basolateral membranes in physiology and disease

This study investigates fatty acid uptake by renal tubule epithelial cells in mice, showing uptake from both blood and urine, and storage as neutral lipids, with CD36 playing a key role in blood-derived uptake.

Environmental pH signals the release of monosaccharides from cell wall in coral symbiotic alga

The paper shows that low pH triggers cellulase-mediated release of monosaccharides from algal cell walls in coral symbionts.

Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains

This study compares the activation of the NLRP3 inflammasome and programmed cell death by different Acinetobacter baumannii strains in macrophages and mice, revealing strain-specific differences in virulence and immune response.

Subacute SARS-CoV-2 replication can be controlled in the absence of CD8+ T cells in cynomolgus macaques

This study shows that subacute SARS-CoV-2 replication can be controlled without CD8+ T cells in cynomolgus macaques, suggesting CD8+ T-cell dysfunction may not solely cause viral control failure.

POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

The ATF6β-calreticulin axis protects hippocampal neurons against endoplasmic reticulum stress and excitotoxicity

This study shows that ATF6β-calreticulin protects hippocampal neurons from ER stress and excitotoxicity by maintaining Ca2+ homeostasis.

Chloroplast acquisition without the gene transfer in kleptoplastic sea slugs, Plakobranchus ocellatus

This study sequenced the genome of a kleptoplastic sea slug and found no evidence of algal gene transfer to the nucleus, showing photosynthesis can occur without nuclear gene transfer.

A comprehensive framework for handling location error in animal tracking data

This paper introduces a framework for handling location error in animal tracking data, showing that error-model selection improves analysis accuracy across various tracking devices and species.

Spatial organization of cortical actin alignments for the ooplasmic segregation of ascidian Ciona eggs

The paper uses fluorescence polarization microscopy to observe cortical actin alignments in Ciona eggs during ooplasmic segregation, showing their role in cytoplasmic reorganization.