K. Arora

T2R14 mediated antimicrobial responses through interactions with CFTR

The paper investigates the interaction between T2R14 and CFTR, showing agonist-dependent physical coupling and Gq signaling in response to microbial signals.

STING-Activating Polymer-Drug Conjugates for Cancer Immunotherapy

This paper develops SAPCon, a polymer-drug conjugate that activates the STING pathway in tumors, enhancing immunotherapy efficacy by promoting an immunogenic microenvironment and improving tumor growth inhibition.

A potential acoustic role for CFTR ion channel in conductive hearing loss

This study investigates the role of CFTR in conductive hearing loss by analyzing middle ear cell composition and gene expression in CF and WT mice.

Nucleoid-Associated Proteins Undergo Liquid-Liquid Phase Separation with DNA into Multiphasic Condensates Resembling Bacterial Nucleoids

The paper shows NAPs like HU-A, HU-B, and Dps form multiphasic condensates with DNA, resembling bacterial nucleoids through phase separation.

Differential pathogenesis of SARS-CoV-2 variants of concern in human ACE2-expressing mice

This study compares the pathogenesis of SARS-CoV-2 variants in human ACE2-expressing mice, finding that some variants are more lethal and replicate more in the lungs and brain.

SARS-CoV-2 variants of concern infect the respiratory tract and induce inflammatory response in wild-type laboratory mice

This study infects wild-type mice with SARS-CoV-2 variants to show B.1.1.7 and B.1.351 replicate more efficiently and induce stronger inflammatory responses than the original B.1 virus.

N-terminal extensions strengthen hydrophobic inter-subunit interactions between HU's C-terminal domains to frustrate heterodimer formation

The paper shows that N-terminal extensions in HU proteins reduce heterodimer formation by stabilizing hydrophobic interactions in the C-terminal domains.

Neuroinvasion and encephalitis following intranasal inoculation of SARS-CoV-2 in K18-hACE2 mice

This study shows that SARS-CoV-2 causes neuroinvasion and encephalitis in K18-hACE2 mice, leading to 100% mortality by day 6 post-infection.

PRAK-03202: A triple antigen VLP vaccine candidate against SARS CoV-2

This paper develops a triple antigen VLP vaccine candidate, PRAK-03202, against SARS-CoV-2 and shows it induces neutralizing antibodies and Th1 immune responses in mice.

Mechanism of bacterial adhesion and embedment in a DNA biofilm matrix:Evidence that binding of outer membrane lipopolysaccharide (LPS) to HU is key

The paper identifies HU's role in bacterial adhesion to DNA in biofilms by binding LPS to HU's DNA-binding sites, facilitating bacterium-bacterium and bacterium-DNA interactions.

The FDA-approved gold drug Auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells

This study shows that auranofin inhibits SARS-CoV-2 replication and reduces inflammation in human cells, suggesting its potential as a therapeutic option for COVID-19.

Multi-Antigenic Virus-like Particle of SARS CoV-2 produced in Saccharomyces cerevisiae as a vaccine candidate

The paper reports the production of a multi-antigenic SARS CoV-2 virus-like particle (VLP) in Saccharomyces cerevisiae as a vaccine candidate, confirmed by TEM and analytical data.

Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia: A report from the TARGET initiative

The paper identifies genetic mechanisms of primary chemotherapy resistance in pediatric AML through whole-genome and transcriptome sequencing of treatment-failure cases.

Structure of Zip2:Spo16, a conserved XPF:ERCC1-like complex critical for meiotic crossover formation

The paper determines the structure of the Zip2:Spo16 complex, showing it binds DNA structures in meiotic recombination and is critical for crossover formation.

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors

This study identifies PGBD5 as an oncogenic DNA transposase in rhabdoid tumors, causing site-specific genomic rearrangements through PSS sequences and end-joining repair.