K. James

IFNγ modestly contributes to disease progression in the Ndufs4(-/-) model of Leigh syndrome while IP10 is dispensable

Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4(KO) model of Leigh syndrome

This study shows that peripheral macrophages contribute to CNS lesions in the Ndufs4(-/-) Leigh syndrome model, despite microglia depletion having limited effect.

Leukocyte proliferation mediates disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome

The paper shows that leukocyte proliferation drives Leigh syndrome pathology in Ndufs4(KO) mice, and leukocyte depletion prevents CNS lesions and extends survival.

Sexually dimorphic placental responses to maternal SARS-CoV-2 infection

The paper investigates sex differences in placental responses to maternal SARS-CoV-2 infection, finding sex-specific changes in interferon genes, Fc-receptor expression, and antibody transfer.

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

RNA polymerase active centre compensates for the absence of transcription proofreading factors in Cyanobacteria

The paper investigates how cyanobacteria compensate for lacking transcription proofreading factors by showing their RNA polymerase actively compensates through structural changes, with trade-offs in regulatory pausing.

Habitat heterogeneity drives scale-dependent biodiversity loss in a temperate marine ecosystem

The paper examines how local habitat heterogeneity influences biodiversity loss in kelp beds affected by climate stressors over two decades.