K. Ryan

Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling

This study shows that dietary protein restriction reduces sucrose consumption and mesolimbic dopamine signaling in mice.

First endangered black-footed ferrets, Mustela nigripes, cloned for genetic rescue

Researchers cloned an endangered black-footed ferret using cross-species somatic cell nuclear transfer, producing three healthy kits to aid genetic rescue.

Warfarin analogs target disulfide bond-forming enzymes and suggest a residue important for quinone and coumarin binding

The paper identifies a conserved residue critical for quinone and coumarin binding in disulfide bond-forming enzymes and demonstrates the potential of warfarin analogs as anticoagulants or antibacterials.

RSV-induced Expanded Ciliated Cells Contribute to Bronchial Wall Thickening

This study identifies RSV-induced actin cytoskeleton expansion in ciliated cells as a novel mechanism contributing to bronchial wall thickening in adults.

Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.

Comparative genomics identified a genetic locus in plant-associated Pseudomonas spp. that is necessary for induced systemic susceptibility

1H MR Spectroscopy of the Motor Cortex Immediately following Transcranial Direct Current Stimulation at 7 Tesla

This study uses 7T MRI to measure metabolite changes in the motor cortex after bihemispheric tDCS, finding a trend toward increased NAA/tCr and a strong correlation between NAA and tCr changes.

Activated BAX/BAK enable mitochondrial inner membrane permeabilisation and mtDNA release during cell death

This study shows that BAX/BAK-mediated mitochondrial outer membrane pores widen after MOMP, leading to inner membrane permeabilisation and mtDNA release, which triggers inflammation via cGAS-STING.