S. Xiong

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

Bioinformatic and Experimental Characterization of the RBM15 RNA Binding Protein

This study characterizes RBM15's RNA binding mechanism through bioinformatics and experiments, showing it interacts with stem-loop RNA motifs via RRMs 2 and 3.

Single-Cell Phylogenetic Tracing Maps the Landscape of Human Tumor Immune Cell Plasticity Driven by Microenvironment Factors-Mediated Epigenetic Reprogramming

This study maps immune cell plasticity in human tumors using lineage tracing and reveals microenvironment-driven epigenetic reprogramming as a key mechanism.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

Stem cell-free therapy for glaucoma to preserve vision

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

Enhanced lipogenesis through Pparγ helps cavefish adapt to food scarcity.

This study shows that cavefish enhance lipogenesis via upregulated Pparγ to store more fat, aiding adaptation to nutrient scarcity.

Mycobacteria tuberculosis PPE36 modulates host inflammation by promoting E3 ligase Smurf1-mediated MyD88 degradation

This study identifies PPE36 as a Mycobacterium tuberculosis protein that modulates host inflammation by promoting Smurf1-mediated MyD88 degradation, enhancing bacterial survival.

Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers predicting HBsAg loss

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

How do three cytosolic glutamine synthetase isozymes of wheat perform N assimilation and translocation?

The paper examines the roles of three wheat glutamine synthetase isozymes in nitrogen assimilation and translocation, showing distinct functions and synergistic effects.

Oncoprotein CoAA repeats interact with RNA polymerase II CTD repeats

This study shows that the oncoprotein CoAA interacts with RNA polymerase II CTD repeats, explaining the functional requirement of diheptad repeats in transcription and alternative splicing.