K. Leon

Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains

This study uses cryo-EM and single-molecule FRET to show conformational coupling between the extracellular and transmembrane domains of an aGPCR, revealing how ECR dynamics influence receptor function.

The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling

This study investigates how the CUB domain of ADGRG6 regulates receptor signaling by modulating conformational dynamics of the extracellular region.

Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

This study develops an antibody that specifically modulates ADGRL3 function without affecting ADGRL1, demonstrating isoform- and ligand-specific aGPCR modulation.

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

Structure of the teneurin-latrophilin complex: Alternative splicing controls synapse specificity by a novel mechanism

The paper reports the cryo-EM structure of the Tenm2-Lphn3 complex and shows how alternative splicing regulates synapse specificity by affecting access to the Lphn-binding site.

Structural basis for adhesion G protein-coupled receptor Gpr126 function

This study determines the structure of the zebrafish Gpr126 ECR, revealing a closed conformation stabilized by alternative splicing and a calcium-binding site, and shows how these features regulate receptor function.