P. Dutka

Directed Evolution of Acoustic Reporter Genes Using High-Throughput Acoustic Screening

The paper evolves acoustic reporter genes using high-throughput acoustic screening to enhance nonlinear ultrasound scattering.

Structural analysis and conformational dynamics of a holo-adhesion GPCR reveal interplay between extracellular and transmembrane domains

This study uses cryo-EM and single-molecule FRET to show conformational coupling between the extracellular and transmembrane domains of an aGPCR, revealing how ECR dynamics influence receptor function.

Ultrasonic reporters of calcium for deep tissue imaging of cellular signals

This paper introduces a genetically encoded ultrasonic calcium reporter (URoC) for noninvasive in vivo imaging of calcium signaling in mammals.

Structure and Function of the Dot/Icm T4SS

This study constructs a nearly-complete model of the Legionella pneumophila Dot/Icm T4SS using subtomogram averaging and integrative modeling, revealing structural insights into six new components and their functional interactions.

Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder

This study develops an antibody that specifically modulates ADGRL3 function without affecting ADGRL1, demonstrating isoform- and ligand-specific aGPCR modulation.

Structural remodeling of Coxiella burnetii during its biphasic developmental cycle revealedby cryo-electron tomography

This study uses cryo-electron tomography to reveal structural changes in Coxiella burnetii during its biphasic developmental cycle, showing morphological transitions and T4BSS-associated structures.

Geometric effects in gas vesicle buckling under ultrasound

This study investigates how the geometry of gas vesicles affects their buckling behavior under ultrasound, showing diameter has an inverse cubic effect on buckling pressure while length has minimal impact.

Dynamic structural adaptations enable the endobiotic predation of bdellovibrio bacteriovorus

This study uses cryo-electron tomography to image the predation cycle of Bdellovibrio bacteriovorus, revealing structural adaptations during prey invasion and replication.

Bimodally oriented cellulose fibers and reticulated homogalacturonan networks - A direct visualization of Allium cepa primary cell walls

This study visualizes the ultrastructure of onion cell walls, revealing bimodal cellulose fiber orientation and HG-rich meshing networks.

Genomically mined acoustic reporter genes enable real-time in vivo monitoring of tumors and tumor-homing probiotics

The paper develops improved acoustic reporter genes for real-time in vivo tumor and therapeutic bacteria monitoring in mouse models.

Measuring gas vesicle dimensions by electron microscopy

The paper explains discrepancies in gas vesicle diameter measurements and provides accurate methods using electron microscopy.